Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2012-06-30

Brief Summary

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The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

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Detailed Description

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Conditions

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Healthy Men Raised Fasting Plasma Triacylglycerol Concentrations

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Native palm olein

75 g native palm olein

Group Type ACTIVE_COMPARATOR

High-fat meal containing native palm olein

Intervention Type DIETARY_SUPPLEMENT

Interesterified palm olein

75 g interesterified palm olein

Group Type EXPERIMENTAL

High-fat meal containing interesterified palm olein

Intervention Type DIETARY_SUPPLEMENT

Interventions

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High-fat meal containing native palm olein

Intervention Type DIETARY_SUPPLEMENT

High-fat meal containing interesterified palm olein

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy males
* Non-smokers
* Aged 40-70 years
* Fasting TAG concentrations ≥1.5 mmol/L.

Exclusion Criteria

* Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease.
* Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.
* History of substance abuse or alcoholism (previous weekly alcohol intake \>60 units/men)
* Current self-reported weekly alcohol intake exceeding 28 units
* Allergy or intolerance to any component of test meals
* Unwilling to restrict consumption of any source of fish oil for the length of the study
* Weight change of \>3kg in preceding 2 months
* Body Mass Index \<20 and \>35 kg/m2
* Fasting blood cholesterol \> 7.8 mmol/L
* Current cigarette smoker.
* Current use of lipid lowering medication

Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes