Imaging Assessment of Diastolic Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Brief Summary

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Diastolic function is poorly studied in children with congenital heart disease. This is mainly due to the lack of validated techniques. Cardiac MRI offers two advantages compared to echocardiography: 1. accurate measurements of ventricular volumes and mass; 2. tissue characterization. The main advantage of echocardiography is a better temporal resolution which allows the study of short events like early relaxation. Overall there is a lack of studies correlating different echocardiographic and MRI parameters of heart function in pediatric populations with congenital or acquired heart diseases. This study will address specific questions on specific groups of patients that might bring more insight into chamber interaction and cardiac function. This study hypothesizes the following:

* Atrial enlargement is a marker of chronic increase in filling pressures and 3D echo might be the best method for follow-up.
* Cardiac remodeling associated with chronic loading results in changes in diastolic properties related to changes in cardiac mass and volume. This is related to changes in cardiac mechanics influencing diastolic parameters. Especially the influence on twisting and untwisting will be studied.
* Regional myocardial fibrosis and scarring may account for regional systolic and diastolic dysfunction with possible prognostic impact

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Detailed Description

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Conditions

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Congenital Heart Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Magnetic Resonance Imaging (MRI)

Subjects with congenital heart disease will undergo an echocardiograph, as well as an MRI.

Group Type EXPERIMENTAL

Echocardiograph

Intervention Type PROCEDURE

Magnetic Resonance Imaging (MRI)

Intervention Type PROCEDURE

Echocardiograph

Subjects with congenital heart disease will undergo an echocardiograph, as well as an MRI.

Group Type EXPERIMENTAL

Echocardiograph

Intervention Type PROCEDURE

Magnetic Resonance Imaging (MRI)

Intervention Type PROCEDURE

Interventions

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Echocardiograph

Intervention Type PROCEDURE

Magnetic Resonance Imaging (MRI)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* All patients with tetralogy of Fallot post repair, transposition of great arteries after arterial switch operation, aortic valvulopathy (aortic stenosis and aortic regurgitation), coarctation of the aorta and cardiomyopathy, who are planned to undergo a cardiac MRI will be eligible.
* Informed consent