Manganese-Enhanced Magnetic Resonance Imaging of the Myocardium

NCT ID: NCT03607669

Last Updated: 2024-05-17

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-06-01
• Study Completion Date: 2020-02-01

Brief Summary

Scanning the heart using magnetic resonance imaging (MRI) enables detailed assessment of its structure and function. MRI can give more detailed information about the heart by using a contrast 'dye' that is injected into a vein during the scan. This can highlight abnormal areas within the heart. Current contrast dyes help identify scarring within the heart, which is useful in people who have had heart attacks. The investigators plan to test new contrast dye containing manganese, which works differently to current agents. They believe it will provide unique insight into how the heart works.

There are many different causes of heart problems and the investigators plan to use this new contrast agent to scan three patient groups; (i) heart disease caused by heart attacks, (ii) heart disease with abnormal thickening of the heart muscle, and (iii) heart disease where the heart becomes stretched and enlarged. Healthy volunteers will be scanned for comparison.

The study will be carried out at the Royal Infirmary of Edinburgh. Adults between 18 and 65 with stable heart failure can be considered. Women who may be pregnant are unable to participate, as is anyone who has some types of metal in their body, as these people can't have an MRI scan safely. All participants will have 2 MRI scans lasting about an hour each, at least 2 days apart. Some participants will be have 4 MRI scans, over a longer time period. The investigators will also take some blood samples and record a tracing of the heart rhythm and will ensure there are no abnormal side-effects by telephone follow up.

The investigators believe this new agent has potential to better measure disease in the heart, improve the ability to establish the cause of heart disease and help monitor the disease over time as well as guide future treatment for individual patients.

Conditions

Ischemic Cardiomyopathy; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Healthy Controls

Healthy volunteers of similar age and gender

Mangafodipir trisodium

Intervention Type: OTHER

Manganese-based MRI contrast agent

Ischaemic Cardiomyopathy

Patients with ischaemic cardiomyopathy and NYHA II-III heart failure

Mangafodipir trisodium

Intervention Type: OTHER

Manganese-based MRI contrast agent

Hypertrophic Cardiomyopathy

Patients with hypertrophic cardiomyopathy and NYHA II-III heart failure

Mangafodipir trisodium

Intervention Type: OTHER

Manganese-based MRI contrast agent

Dilated Cardiomyopathy

Patients with dilated cardiomyopathy and NYHA II-III heart failure

Mangafodipir trisodium

Intervention Type: OTHER

Manganese-based MRI contrast agent

Interventions

Mangafodipir trisodium

Manganese-based MRI contrast agent

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

All subjects to be entered must:

• ≥ 18 years of age
• if female, be non-pregnant as evidenced by a urine pregnancy test or post-menopausal or surgically sterile
• provide written informed consent after having received oral and written information about the study

Healthy Volunteers

• Healthy adult with no known pre-existing medical conditions

Ischaemic Cardiomyopathy

• Ischaemic cardiomyopathy as diagnosed by reduced LV ejection fraction (≤40%) secondary to one or more ischaemic events
• Angiographically demonstrated LMS, LAD disease, or ≥2 vessel disease
• NHYA class I-III heart failure, with stable symptoms not requiring change to diuretic therapy in the preceding month

Dilated Cardiomyopathy

• Dilated cardiomyopathy characterised with echocardiography by reduced left ventricular systolic function with impaired systolic function (ejection fraction <40%).
• NHYA class I-III heart failure, with stable symptoms not requiring change to diuretic therapy in the preceding month

Hypertrophic Cardiomyopathy

• Established diagnosis of hypertrophic cardiomyopathy
• Left ventricular wall thickness ≥15mm in any segment
• Repolarisation abnormalities on 12-lead electrocardiogram NHYA class I-III heart failure, with stable symptoms not requiring change to diuretic therapy in the preceding month

Exclusion Criteria

• have a positive pregnancy test
• women who are breast feeding
• received an investigational drug or device within 30 days prior to administration of Mangafodipir
• have known hypersensitivity to ondansetron or other selective serotonin 5-HT3 receptor blockers
• have a history of ongoing drug abuse or alcoholism
• have a history of torsades or prolonged QT/QTc interval
• atrioventricular block (1st, 2nd or 3rd degree)
• atrial fibrillation or flutter
• have NYHA Grade IV heart failure
• have abnormal liver function tests or a history of liver disease
• have a baseline eGFR (estimated glomerular filtration rate) of <30 mL/min)
• have uncontrolled hypertension
• have any contraindications to MRI, including implanted devices/pacemakers
• be maintained on either a calcium channel blocker or digoxin
• known diagnosis of phaeochromocytoma

Hypertrophic Cardiomyopathy

• Coronary artery stenosis >50% any vessel
• Previous myocardial infarction
• Previous alcohol septal ablation
• Moderate or severe aortic stenosis (mean gradient >25 mmHg, mean AVA ≤1.5 cm2 or peak velocity ≥3 m/sec),

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Edinburgh

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

David E Newby, MD PhD

Role: STUDY_DIRECTOR

University of Edinburgh

Locations

Queen's Medical Research Institute, University of Edinburgh

Edinburgh, Midlothian, United Kingdom

Countries

United Kingdom

References

Spath NB, Singh T, Papanastasiou G, Baker A, Janiczek RJ, McCann GP, Dweck MR, Kershaw L, Newby DE, Semple S. Assessment of stunned and viable myocardium using manganese-enhanced MRI. Open Heart. 2021 Jun;8(1):e001646. doi: 10.1136/openhrt-2021-001646.

Reference Type: DERIVED

PMID: 34099530 (View on PubMed)

Other Identifiers

AC16109

Identifier Type: -

Identifier Source: org_study_id