Optimisation and Quantification of Contrast Enhanced Computed Tomography Myocardial Fibrosis Imaging

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Study Completion Date

2023-05-31

Brief Summary

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Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients and not tolerated by others. Computed tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the heart. This study will assess CT imaging of the heart muscle of patients who have previously undergone MRI of their heart. Using a state of the art CT scanner the investigators will develop a low radiation dose protocol to identify scarred heart muscle. The investigators will use and develop software techniques to analyse these images. This will enable us to develop a new way to identify and measure scarred heart muscle that will benefit patients with heart disease.

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Detailed Description

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Conditions

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Myocardial Infarction

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Participants

Participants will have previously had an MRI scan and will undergo a CT scan.

Computed tomography late enhancement imaging

Intervention Type RADIATION

Interventions

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Computed tomography late enhancement imaging

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Presence of late enhancement on magnetic resonance imaging

Exclusion Criteria

* age less than 40
* inability or unwillingness to undergo CT
* renal failure (serum creatinine \>200 umol/l or estimated glomerular filtration rate \<30 ml/min)
* hepatic failure
* allergy to iodinated contrast
* pregnancy
* breast feeding
* inability to undergo informed consent
* fast atrial fibrillation

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No