Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
16 participants
OBSERVATIONAL
2018-02-01
2024-01-31
Brief Summary
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Detailed Description
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This study will assess the use of PET/MRI with USPIO in patients with stable coronary artery disease and recent acute myocardial infarction.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Healthy volunteers
Healthy volunteers to undergo MRI using USPIO contrast
MRI
MRI with USPIO contrast
Stable coronary artery disease
Patients with coronary artery disease without recent (3 months) acute coronary syndrome or revascularisation
PET/MRI
PET/MRI with USPIO contrast
Recent acute coronary syndrome
Patients with recent (3 months) type 1 myocardial infarction
PET/MRI
PET/MRI with USPIO contrast
Interventions
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PET/MRI
PET/MRI with USPIO contrast
MRI
MRI with USPIO contrast
Eligibility Criteria
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Inclusion Criteria
* Patients with coronary artery disease to undergo PET/MRI will have multi-vessel disease (≥2 vessel coronary artery disease with ≥ 50% cross-sectional luminal stenosis).
* able to provide informed consent
* over the age of 40 years
Exclusion Criteria
* renal failure (Serum creatinine \>200 umol/L or estimated glomerular filtration rate \<30 mL/min
* hepatic failure
* pregnancy
* inability to provide informed consent
* contraindications to undergoing MRI scanning
* contraindications to contrast agents not included above including evidence of iron overload, known allergy to constituents of the contrast agents, and anaemia not caused by iron deficiency
40 Years
ALL
Yes
Sponsors
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University of Edinburgh
OTHER
Responsible Party
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Principal Investigators
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Michelle Williams
Role: PRINCIPAL_INVESTIGATOR
University of Edinburgh
Locations
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Royal Infirmary of Edinburgh
Edinburgh, Scotland, United Kingdom
Countries
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Other Identifiers
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17/SS/0151
Identifier Type: -
Identifier Source: org_study_id
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