Robot Assisted Laparoscopic Hysterectomy vs. Abdominal Hysterectomy in Endometrial Cancer

NCT ID: NCT01526655

Last Updated: 2024-04-18

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-25

Study Completion Date

2016-07-27

Brief Summary

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The purpose of the trial is to determine whether robot assisted laparoscopic hysterectomy compared with abdominal hysterectomy in a fast track program gives a faster recovery postoperatively, causes less tissue damage and less effects on the immunological system, and is health economically cost-effective.

Detailed Description

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If detailed description is requested, please contact sponsor.

Conditions

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Endometrial Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Abdominal total hysterectomy

Standard extrafascial abdominal total hysterectomy through a low transverse abdominal wall incision

Group Type ACTIVE_COMPARATOR

Abdominal total hysterectomy

Intervention Type PROCEDURE

Abdominal total hysterectomy through a low transverse abdominal wall incision

Robot assisted laparoscopic hysterectomy

Robot assisted laparoscopic total hysterectomy

Group Type ACTIVE_COMPARATOR

Robot assisted laparoscopic hysterectomy

Intervention Type PROCEDURE

Robot assisted laparoscopic total hysterectomy

Interventions

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Abdominal total hysterectomy

Abdominal total hysterectomy through a low transverse abdominal wall incision

Intervention Type PROCEDURE

Robot assisted laparoscopic hysterectomy

Robot assisted laparoscopic total hysterectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Over 18 years of age.
* Scheduled to total hysterectomy + bilateral salpingooophorectomy (BSAE) and peritoneal lavage because of endometrial carcinoma, International federation of gynecology and obstetrics (FIGO) stage 1, grade 1 and 2, with diploid DNA profile (i.e. low risk profile).
* WHO (World Health Organisation) performance status ≤ 2.
* Proficiency in Swedish
* Accept to participate in the study and has signed written informed consent document.
* The operation should be considered possible to be perform laparoscopically and by laparotomy through a low transverse abdominal wall incision.

Exclusion Criteria

* The operation is anticipated to comprise more than the hysterectomy + BSAE.
* A midline incision is planned for the laparotomy.
* Contraindications towards spinal anesthesia with intrathecally applied morphine.
* Physically disabled women who cannot be expected to be mobilized in accordance to the fast track program in a way similar to what is expected from not-physically disabled women.
* Mentally disabled women who cannot fill in the questionnaires or understand the consequences of participating in a trial.
* Severe psychiatric disease or on medication for psychiatric disease so that the physician consider participation in the trial inappropriate.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Linkoeping

OTHER

Sponsor Role lead

Responsible Party

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Preben Kjolhede, MD, professor

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Preben Kjölhede, MD, PhD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, 58185 Linköping, Sweden

Evelyn Lundin, MD

Role: STUDY_DIRECTOR

Department of Obstetrics and Gynecology, University Hospital, 58185 Linköping, Sweden

Ninnie Borendal Wodlin, MD, PhD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, 58185 Linköping, Sweden

Lena Nilsson, MD, PhD

Role: STUDY_CHAIR

Department of Anesthesiology, University Hospital, 58185 Linköping, Sweden

Jan Ernerudh, MD, PhD

Role: STUDY_CHAIR

Department of Clinical Immunology, University Hospital, 58185 Linköping, Sweden

Per Carlsson, PhD

Role: STUDY_CHAIR

Centre for Medical Technology Assessment, University Hospital, 58185 Linköping, Sweden

Locations

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Department of Obstetrics and Gynecology, Ryhov Central Hospital

Jönköping, Jönköping County, Sweden

Site Status

Department of Obstetrics and Gynecology, University Hospital

Linköping, Östergötland County, Sweden

Site Status

Countries

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Sweden

Other Identifiers

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ROBOTHYST

Identifier Type: -

Identifier Source: org_study_id

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