Follow-up Strategies for Improved Postoperative Recovery After Benign Hysterectomy

NCT ID: NCT01526668

Last Updated: 2022-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

525 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-11

Study Completion Date

2018-01-31

Brief Summary

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The purpose of the study is to investigate the effect of four different follow-up strategies on postoperative recovery following vaginal or abdominal hysterectomy for benign conditions. Furthermore the investigators aim to examine associations between preoperative thresholds for pain (thermal and pressure) and postoperative pain and development of chronic pelvic pain after benign hysterectomy.

Detailed Description

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Contact sponsor if detailed information is requested.

Conditions

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Hysterectomy Genital Diseases, Female Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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No contact after discharge

In Arm A: The patient do not have planned contacts with the study nurse or doctor after discharge. All patients are seen by the study nurse six weeks postoperatively.

Group Type ACTIVE_COMPARATOR

No contact after discharge

Intervention Type BEHAVIORAL

Single telephone contact

In Arm B: The patient has one planned telephone contact with the study nurse the day after discharge. All patients are seen by the study nurse six weeks postoperatively.

Group Type ACTIVE_COMPARATOR

Follow-up strategy

Intervention Type BEHAVIORAL

Comparison of different follow-up strategies

Telephone contacts regularly

In Arm C: The patient has planned telephone contacts with the study nurse the day after discharge and then once weekly until the six weeks follow-up visit postoperatively.

Group Type ACTIVE_COMPARATOR

Follow-up strategy

Intervention Type BEHAVIORAL

Comparison of different follow-up strategies

Telephone contact using CBT-inspired strategy

In Arm C: The patient has planned telephone contacts with the study nurse the day after discharge and then once weekly until the six weeks follow-up visit postoperatively. At these telephone contacts the study nurse uses a cognitive behavior therapy (CBT)-inspired strategy in counselling and support.

Group Type ACTIVE_COMPARATOR

Follow-up strategy

Intervention Type BEHAVIORAL

Comparison of different follow-up strategies

Interventions

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Follow-up strategy

Comparison of different follow-up strategies

Intervention Type BEHAVIORAL

No contact after discharge

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Women between 18 and 60 years of age.
* Women who are scheduled for vaginal or abdominal total or subtotal hysterectomy for benign gynecological diseases (including cervical dysplasia).
* Women who understand and speak Swedish fluently.
* Women who gives signed informed consent to participate in the study.
* Women who have access to a telephone and/or internet.

Exclusion Criteria

* Women where the hysterectomy is carried out in association with surgery for genital prolapse
* Women with genital malignancies (does not include cervical dysplasia).
* Women where the operation is planned or expected to comprise more than the hysterectomy with or without unilateral salpingooophorectomy and appendectomy en passant.
* Women with previous bilateral salpingooophorectomy.
* Women who are physically disabled to a degree so that mobilization postoperatively cannot be expected as for a normal individual.
* Women who are mentally disabled to a degree so she cannot complete the forms in the study or understand the tenor of the participation or it is considered doubtful from an ethical point of view to participate.
* Women with psychiatric disease or is on medication for severe psychiatric disease so that the physician consider participation in the study unsuitable.
* Women with current drug or alcohol abuse.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Linkoeping

OTHER

Sponsor Role lead

Responsible Party

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Preben Kjolhede, MD, professor

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Preben Kjolhede, MD, PhD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, 58185 Linkoping, Sweden

Ninnie Borendal Wodlin, MD, PhD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, S-58185 Linkoping, Sweden

Lena Nilsson, MD, PhD

Role: STUDY_CHAIR

Department of Anesthesiology, University Hospital, S-58185 Linkoping, Sweden

Gunilla Sydsjo, PhD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, S-58185 Linkoping, Sweden

Gulnara Kassymova, MD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, S-58185 Linkoping, Sweden

Peter Lukas, MD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, University Hospital, S-58185 Linkoping, Sweden

Björn Gerdle, MD, PhD

Role: STUDY_CHAIR

Pain and Rehabilitation Center, University Hospital, 581 85 Linkoping, Sweden

Locations

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Department of Obstetrics and Gynecology, Höglandshospital

Eksjö, Jonkopings Län, Sweden

Site Status

Department of Obstetrics and Gynecology, Ryhov Central Hospital

Jönköping, Jonkopings Län, Sweden

Site Status

Department of Obstetrics and Gynecology

Värnamo, Jonkopings Län, Sweden

Site Status

Department of Obstetrics and Gynecology, University Hospital

Linköping, Östergötland County, Sweden

Site Status

Department of Obstetrics and Gynecology, Vrinnevi Hospital

Norrköping, Östergötland County, Sweden

Site Status

Countries

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Sweden

References

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Kassymova G, Davidson T, Sydsjo G, Wodlin NB, Nilsson L, Kjolhede P. Cost analysis of nurse-lead telephone follow-ups after benign hysterectomy: a randomized, single-blinded, four-arm, controlled multicenter trial. Arch Gynecol Obstet. 2025 Aug;312(2):515-523. doi: 10.1007/s00404-025-08035-1. Epub 2025 May 2.

Reference Type DERIVED
PMID: 40314809 (View on PubMed)

Lukas P, Nilsson L, Wodlin NB, Arendt-Nielsen L, Kjolhede P. Changes in spatial bodily pain distribution one year after benign hysterectomy with emphasis on prevalence and risk factors for de novo and persistent pelvic pain- a prospective longitudinal multicenter study. BMC Womens Health. 2024 Dec 20;24(1):644. doi: 10.1186/s12905-024-03474-5.

Reference Type DERIVED
PMID: 39707275 (View on PubMed)

Kassymova G, Sydsjo G, Borendal Wodlin N, Nilsson L, Kjolhede P. The Impact of Symptoms of Depression, Anxiety, and Low Stress-Coping Capacity on the Effects of Telephone Follow-Up on Recovery Measures After Hysterectomy. Womens Health Rep (New Rochelle). 2024 Mar 27;5(1):304-318. doi: 10.1089/whr.2023.0045. eCollection 2024.

Reference Type DERIVED
PMID: 38558946 (View on PubMed)

Kassymova G, Sydsjo G, Wodlin NB, Nilsson L, Kjolhede P. Effect of nurse-led telephone follow-up on postoperative symptoms and analgesics consumption after benign hysterectomy: a randomized, single-blinded, four-arm, controlled multicenter trial. Arch Gynecol Obstet. 2023 Feb;307(2):459-471. doi: 10.1007/s00404-022-06722-x. Epub 2022 Sep 2.

Reference Type DERIVED
PMID: 36050542 (View on PubMed)

Kassymova G, Sydsjo G, Borendal Wodlin N, Nilsson L, Kjolhede P. The Effect of Follow-Up Contact on Recovery After Benign Hysterectomy: A Randomized, Single-Blinded, Four-Arm, Controlled Multicenter Trial. J Womens Health (Larchmt). 2021 Jun;30(6):872-881. doi: 10.1089/jwh.2020.8752. Epub 2020 Nov 24.

Reference Type DERIVED
PMID: 33232628 (View on PubMed)

Other Identifiers

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POSTHYSTREC

Identifier Type: -

Identifier Source: org_study_id

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