Robotic Versus Abdominal Surgery for Endometrial Cancer

NCT ID: NCT01847703

Last Updated: 2018-03-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2017-07-31

Brief Summary

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This study is intended to explore differences in oncologic and surgical safety between robotic assisted laparoscopy and conventional abdominal surgery for high risk endometrial cancer.

Detailed Description

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Hypothesis: Robotic assisted laparoscopy (RAL)is equal in terms of oncologic and surgical safety as conventional abdominal surgery (AS) for high risk endometrial cancer (EC).

Methods: Women with high risk EC (defined as high grade endometrial, clear cell or serous) are randomized to either RAL or AS. Both groups will undergo complete surgical staging (hysterectomy, bilateral salpingoophorectomy, pelvic and paraaortal lymphadenectomy)

Primary endpoint: Number of harvested lymph nodes per station Secondary endpoints: Recurrences up to 3 year after surgery. Lymphatic side-effects, quality of life, cost, surgical morbidity.

Conditions

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Endometrial Neoplasms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Robotic surgery

Experimental method, to be compared with standard care

Group Type EXPERIMENTAL

Robotic surgery

Intervention Type PROCEDURE

Minimal invasive surgery performed with daVinci robotic system

Abdominal surgery

Conventional open surgery (laparotomy)

Group Type ACTIVE_COMPARATOR

Abdominal surgery

Intervention Type PROCEDURE

Current gold standard

Interventions

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Robotic surgery

Minimal invasive surgery performed with daVinci robotic system

Intervention Type PROCEDURE

Abdominal surgery

Current gold standard

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18-75 years of age
* High risk endometrial cancer

Exclusion Criteria

* WHO performance\>1
* Severe comorbidity, ASA\>3
* Unable to understand information
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Henrik Falconer

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Henrik Falconer, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Karolinska Institutet

Locations

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Karolinska University Hospital

Stockholm, , Sweden

Site Status

Countries

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Sweden

References

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Salehi S, Avall-Lundqvist E, Legerstam B, Carlson JW, Falconer H. Robot-assisted laparoscopy versus laparotomy for infrarenal paraaortic lymphadenectomy in women with high-risk endometrial cancer: A randomised controlled trial. Eur J Cancer. 2017 Jul;79:81-89. doi: 10.1016/j.ejca.2017.03.038. Epub 2017 Apr 29.

Reference Type DERIVED
PMID: 28463759 (View on PubMed)

Other Identifiers

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2013/361-31/1

Identifier Type: -

Identifier Source: org_study_id

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