Role of Uterine Manipulator in Hysterectomy - Ro.Man.HY

NCT ID: NCT02762214

Last Updated: 2016-05-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

154 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2017-10-31

Brief Summary

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Prospective multicentric randomized trial to evaluate the role of uterine manipulator on laparoscopic/robotic total hysterectomy for the treatment of early stage G1 - G2 endometrial cancer (International Federation of Gynecology and Obstetrics - FIGO stages IA-IB).

Detailed Description

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This multicentric prospective randomized Phase III trial is aimed to verify if the use of uterine manipulator for laparoscopic/robotic treatment of early stage endometrial cancer can influence the impact of peritoneal cytology and lymph vascular space invasion (LVSI) and the outcomes in terms of perioperative and oncological (disease free survival - DFS, overall survival - OS) outcomes.

Conditions

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Endometrial Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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With Uterine Manipulator

77 Patients affected by early stage endometrial cancer submitted to elective laparoscopic/robotic hysterectomy for endometrial cancer using uterine manipulator.

Group Type ACTIVE_COMPARATOR

Clermont-Ferrand Uterine Manipulator

Intervention Type DEVICE

Pelvic cytology is obtained before starting surgical procedures (washing number 1).

After tubal coagulation, Clermont-Ferrand Uterine Manipulator is installed inside the uterus. At the end of the hysterectomy, after colporrhaphy, a second cytology is obtained (washing number 2)

Without Uterine Manipulator

77 Patients affected by early stage endometrial cancer submitted to elective laparoscopic/robotic hysterectomy for endometrial cancer without support of uterine manipulator.

Group Type EXPERIMENTAL

No uterine Manipulator

Intervention Type OTHER

Pelvic cytology is obtained before starting surgical procedures (washing number 1). None uterine manipulator is used and the cervix is closed with a cross stitch.

Tubal coagulation, At the end of the hysterectomy, after colporrhaphy, a second cytology is obtained (washing number 2)

Interventions

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Clermont-Ferrand Uterine Manipulator

Pelvic cytology is obtained before starting surgical procedures (washing number 1).

After tubal coagulation, Clermont-Ferrand Uterine Manipulator is installed inside the uterus. At the end of the hysterectomy, after colporrhaphy, a second cytology is obtained (washing number 2)

Intervention Type DEVICE

No uterine Manipulator

Pelvic cytology is obtained before starting surgical procedures (washing number 1). None uterine manipulator is used and the cervix is closed with a cross stitch.

Tubal coagulation, At the end of the hysterectomy, after colporrhaphy, a second cytology is obtained (washing number 2)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

For patients

* Age \> 18 \< 80 years
* Patient's informed consent
* American Society of Anesthesiologists: \< class III or IV
* No actual pregnancies
* Body Mass Index (BMI) ≤ 35

For diseases

* Early stage endometrial cancer (IA-IB)
* Endometrioid histotype (G1-G2)

Exclusion Criteria

For patients

* Age \> 18 \< 80
* Actual pregnancies
* Previous gynecological cancer

For disease

* Type II endometrial cancer histotype
* Grade 3 endometrial cancer
* Advanced stage endometrial cancer (II - IV)
* Previous radiotherapy on the pelvic field
* Uterine size larger than conform 12 weeks gestation or 9 cm in horizontal
* Necessity of laparotomic procedures
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Catholic University of the Sacred Heart

OTHER

Sponsor Role lead

Responsible Party

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Prof. Giovanni Scambia

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Division of Oncologic Gynecology, Fondazione Policlinico Gemelli

Rome, Rome, Italy

Site Status RECRUITING

Countries

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Italy

Facility Contacts

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Salvatore Gueli Alletti

Role: primary

+390630158545

Other Identifiers

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RoManHy

Identifier Type: -

Identifier Source: org_study_id

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