Study Results
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Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2011-08-31
2012-01-31
Brief Summary
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Inulin-type fructans (inulin and oligofructose) are natural food ingredients with prebiotic activity. Fermentation of inulin and oligofructose by lactic acid producing bacteria results in an increase in bacterial biomass and the production of SCFA (acetate, propionate and butyrate), lactic acid and the gases CO2 and H2. They are naturally present in significant amounts in several vegetables such as garlic, artichoke, onion, asparagus, leek and wheat (1-4%). Based on consumption data, the daily intake of inulin in Europe varies between 3.2 and 11.3g mainly from wheat (2-7.8g/d). However, this might have changed recently since inulin and oligofructose are used by the food industry either as sucrose and fat replacements or due to their health benefits for the human host.
Several human absorption studies evaluated the effect of inulin/oligofructose on mineral absorption. It was shown that calcium and magnesium absorption was positively influenced. Until now, the positive effect on iron absorption was only shown in animals. The influence on human iron absorption was investigated twice. Both studies reported no effect of inulin/oligofructose on iron absorption, but this was most likely due to poorly conceived study designs.
The aim of the present study is to demonstrate that inulin consumption over several weeks can lead to enhanced iron absorption in humans under optimized conditions.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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inulin
inulin
20g/day for 4 weeks
maltodextrin
maltodextrin
20g/day for 4 weeks
Interventions
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inulin
20g/day for 4 weeks
maltodextrin
20g/day for 4 weeks
Eligibility Criteria
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Inclusion Criteria
* between 18 and 40 years
* below 65kg
Exclusion Criteria
* long-term medication
* blood donation within 6 month before the study-
18 Years
40 Years
FEMALE
Yes
Sponsors
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Swiss Federal Institute of Technology
OTHER
Responsible Party
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Prof. Michael B. Zimmermann
Prof.
Principal Investigators
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Richard Hurrell, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
ETH Zurich
Locations
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ETH
Zurich, Canton of Zurich, Switzerland
Countries
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References
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Petry N, Egli I, Chassard C, Lacroix C, Hurrell R. Inulin modifies the bifidobacteria population, fecal lactate concentration, and fecal pH but does not influence iron absorption in women with low iron status. Am J Clin Nutr. 2012 Aug;96(2):325-31. doi: 10.3945/ajcn.112.035717. Epub 2012 Jun 27.
Other Identifiers
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INOL
Identifier Type: -
Identifier Source: org_study_id
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