Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
8 participants
OBSERVATIONAL
2009-03-31
2009-12-31
Brief Summary
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The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.
Detailed Description
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8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.
To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.
Conditions
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Keywords
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Study Design
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PROSPECTIVE
Study Groups
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1
Healthy volunteers
test meal
Mixed meal containing bread, butter, beef
glucose
administration of a glucose meal
fat
administration of a lipid meal
protein
administration of a protein meal
control
no meal
Interventions
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test meal
Mixed meal containing bread, butter, beef
glucose
administration of a glucose meal
fat
administration of a lipid meal
protein
administration of a protein meal
control
no meal
Eligibility Criteria
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Inclusion Criteria
* 18-35 years old
* 19 kg/m2 ≤ BMI ≤ 25 kg/m2
* Healthy
* Low to moderate physical activity
* Non smokers
Exclusion Criteria
* Any medication
* Participation to blood spending or other clinical study in the 3 months before the beginning of this study
* Consumption of drugs
* Consumption of more than 50g of alcool in a week
* Vegetarian or particular diet
* Anamnèse d'intolérance alimentaire
* Family history of food intolerance
18 Years
35 Years
MALE
Yes
Sponsors
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Centre Hospitalier Universitaire Vaudois
OTHER
University of Lausanne
OTHER
Responsible Party
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Luc Tappy, MD
professor of physiology
Principal Investigators
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Luc Tappy, MD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire Vaudois
Locations
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Cardiomet Clinical research Center, CHUV
Lausanne, Canton of Vaud, Switzerland
University of Lausanne
Lausanne, , Switzerland
Countries
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References
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Carrel G, Egli L, Tran C, Schneiter P, Giusti V, D'Alessio D, Tappy L. Contributions of fat and protein to the incretin effect of a mixed meal. Am J Clin Nutr. 2011 Oct;94(4):997-1003. doi: 10.3945/ajcn.111.017574. Epub 2011 Aug 17.
Other Identifiers
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162/08/CE/FBM
Identifier Type: -
Identifier Source: org_study_id