Epigenetic Mechanisms and Severe Obesity (Biological Tissue Collection)

NCT ID: NCT02663388

Last Updated: 2016-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2026-01-31

Brief Summary

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The purpose of this study was to evaluate the role of vitamin status and epigenetic mechanisms on severe obesity related-complications.

Detailed Description

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Conditions

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Obesity Diabetes Metabolic Diseases Non-alcoholic Fatty Liver Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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gastric bypass, sleeve, gastric banding

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* indication for bariatric surgery with BMI \> 35 kg/m2

Exclusion Criteria

* unable to receive clear information
* refusal to sign the consent form
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role collaborator

University of Lorraine

OTHER

Sponsor Role lead

Responsible Party

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Laurent Brunaud

Pr Laurent BRUNAUD, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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laurent BRUNAUD, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Lorraine, CHU Nancy

Locations

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University of Lorraine, CHU Nancy

Vandœuvre-lès-Nancy, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Laurent BRUNAUD, MD, PhD

Role: CONTACT

Email: [email protected]

Facility Contacts

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laurent brunaud

Role: primary

laurent brunaud

Role: backup

References

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Antoine D, Li Z, Quilliot D, Sirveaux MA, Meyre D, Mangeon A, Brunaud L, Gueant JL, Gueant-Rodriguez RM. Medium term post-bariatric surgery deficit of vitamin B12 is predicted by deficit at time of surgery. Clin Nutr. 2021 Jan;40(1):87-93. doi: 10.1016/j.clnu.2020.04.029. Epub 2020 Apr 25.

Reference Type DERIVED
PMID: 32444241 (View on PubMed)

Li Z, Gueant-Rodriguez RM, Quilliot D, Sirveaux MA, Meyre D, Gueant JL, Brunaud L. Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. Clin Nutr. 2018 Oct;37(5):1700-1706. doi: 10.1016/j.clnu.2017.07.008. Epub 2017 Jul 24.

Reference Type DERIVED
PMID: 28780990 (View on PubMed)

Other Identifiers

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2015-A01175-44

Identifier Type: -

Identifier Source: org_study_id