The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation
NCT ID: NCT02372526
Last Updated: 2017-02-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
18 participants
OBSERVATIONAL
2015-01-31
2017-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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10 Roux-en-Y gastric bypass patients
Isocaloric amounts of specific macronutrients is mixed with 4 g vegetable bouillon and tested against each others ability to induce GLP-1 secretion. The mealtest takes place at 4 different days with 3-14 days separation.
Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High fat 200 kcal 200 ml liquid meal with pancreatic lipase inhibitor consumed during 10 minutes
10 Healthy Control subjects
Isocaloric amounts of specific macronutrients is mixed with 4 g vegetable bouillon and tested against each others ability to induce GLP-1 secretion. The mealtest takes place at 4 different days with 3-14 days separation.
Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High fat 200 kcal 200 ml liquid meal with pancreatic lipase inhibitor consumed during 10 minutes
Interventions
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Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
Mealtest: High fat 200 kcal 200 ml liquid meal with pancreatic lipase inhibitor consumed during 10 minutes
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Have not underwent bariatric surgery.
Exclusion Criteria
Healthy control subjects:
* Inadequate thyroid substitution, undergoing treatment with drugs known to interact with Orlistat (such as cyclosporine, anticoagulating agents, amiodarone, amlodipine and epileptics), where pausing the treatment with these is not an option. Type 1 or 2 diabetes mellitus now or prior. Serious heart or respiratory illness. Haemoglobin levels below 6,5 mM.
25 Years
55 Years
ALL
Yes
Sponsors
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University of Copenhagen
OTHER
Kirstine Nyvold Bojsen-Moeller
OTHER
Responsible Party
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Kirstine Nyvold Bojsen-Moeller
Postdoc
Locations
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Endocrinology Research Center, Hvidovre University Hospital
Hvidovre, Copenhagen, Denmark
Countries
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Other Identifiers
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CZJ-MA-14
Identifier Type: -
Identifier Source: org_study_id
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