Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures
NCT ID: NCT02160379
Last Updated: 2014-06-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
31 participants
OBSERVATIONAL
2011-01-31
2012-03-31
Brief Summary
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* 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
* 11 age- and weight-matched female subjects
* 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
* electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
* plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
* to evaluate the effects of RYGB on brain perception of food related visual stimulation
* to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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post Roux-en-Y-gastric bypass
Formerly obese females 1-5 years after gastric bypass
standard test meal
matched controls
non-operated females age-and weight-matched to post Roux-en-Y-gastric bypass subjects
standard test meal
healthy young controls
non overweight (BMI between 19 and 25 kg/m2) healthy females
standard test meal
Interventions
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standard test meal
Eligibility Criteria
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Inclusion Criteria
* gender: female
* age 18-50
* non-smoker
Exclusion Criteria
* consumption of more than 50g alcohol per week
* vegetarian or any special diet
18 Years
50 Years
FEMALE
Yes
Sponsors
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University of Lausanne
OTHER
Responsible Party
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Luc Tappy, MD
Professor of Physiology
Principal Investigators
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Luc Tappy, MD
Role: PRINCIPAL_INVESTIGATOR
University of Lausanne
Locations
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CHUV-clinical research center
Lausanne, Canton of Vaud, Switzerland
Countries
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Other Identifiers
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219/09
Identifier Type: -
Identifier Source: org_study_id
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