Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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SUSPENDED
NA
48 participants
INTERVENTIONAL
2013-03-31
2016-12-31
Brief Summary
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This project intends to examine patients' background activity in the brain (i.e. "the resting state activity") and brain volume using MRI both before and one year after surgery.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Bariatric surgery
patients participating in the intervention group , i.e. assessing effects of bariatric surgery on: Brain activity in resting state Memory performance
Bariatric surgery
Gastric bypass surgery
Brain activity in resting state
Measure of activity in brain networks during resting state
Memory performance
Assess concentration in 2D-location task (i.e. "memory game")
Control
Patients in the control group will not undergo surgery during study.
These patients will be examined twice:
1. 9 weeks before the operation (i.e. clinical intervention to reduce body weight has not started).
2. after 4 weeks of low-calorie diet (which will be a week before their surgery, when patients are in a catabolic metabolism because they eat much less energy than is needed) to assess effect of acute weight loss on: Brain activity in resting state Memory performance
Brain activity in resting state
Measure of activity in brain networks during resting state
Memory performance
Assess concentration in 2D-location task (i.e. "memory game")
Interventions
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Bariatric surgery
Gastric bypass surgery
Brain activity in resting state
Measure of activity in brain networks during resting state
Memory performance
Assess concentration in 2D-location task (i.e. "memory game")
Eligibility Criteria
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Inclusion Criteria
* right-handed
* scheduled for bariatric surgery in the Academic Hospital of Uppsala, Sweden
Exclusion Criteria
* suffer from mental disorders (depression, phobias, etc.) that can not be controlled with treatment.
18 Years
65 Years
FEMALE
No
Sponsors
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Uppsala University Hospital
OTHER
Uppsala University
OTHER
Responsible Party
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Principal Investigators
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Magnus Sundbom, MD
Role: STUDY_DIRECTOR
Academic Hospital Uppsala
Christian Benedict, PhD
Role: STUDY_DIRECTOR
Uppsala University
Pleunie Hogenkamp, PhD
Role: PRINCIPAL_INVESTIGATOR
Uppsala University
Locations
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Academic Hospital
Uppsala, , Sweden
Countries
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Other Identifiers
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EPN 2012/451
Identifier Type: OTHER
Identifier Source: secondary_id
PH2013b
Identifier Type: -
Identifier Source: org_study_id
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