Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

NCT ID: NCT02902224

Last Updated: 2016-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Study Completion Date

2016-08-31

Brief Summary

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The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Detailed Description

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Conditions

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Exploratory Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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PLACEBO

Single intragastric instillation of 300ml tap water via nasogastric tube

Group Type PLACEBO_COMPARATOR

Tap water

Intervention Type DIETARY_SUPPLEMENT

300ml tap water via nasogastric tube

GLUCOSE

Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Glucose

Intervention Type DIETARY_SUPPLEMENT

300ml tap water with 75g glucose via nasogastric tube

FRUCTOSE

Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Fructose

Intervention Type DIETARY_SUPPLEMENT

300ml tap water with 25g fructose via nasogastric tube

Interventions

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Tap water

300ml tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Glucose

300ml tap water with 75g glucose via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Fructose

300ml tap water with 25g fructose via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* right-handed
* morbidly obese patients
* scheduled for bariatric surgery

Exclusion Criteria

* Diabetes mellitus
* cardiovascular disease
* neurologic or psychiatric disorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christoph Beglinger, Prof

Role: STUDY_CHAIR

University of Basel

Locations

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University Hospital Basel

Basel, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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fMRI BARI

Identifier Type: -

Identifier Source: org_study_id

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