Effect of Caloric Restriction and Gastric Bypass on Resting Metabolic Rate

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2015-02-28

Brief Summary

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Studies in overweight and obese subjects show a decline in resting metabolic rate (RMR) even after moderate caloric restriction. Yet the onset and course of such a metabolic adaption is still unclear. Lower resting metabolic rates were also reported after gastric banding bariatric surgery but have not yet been investigated in subjects after gastric bypass. The purpose of this study is to investigate the consequences on resting metabolic rate in subjects with obesity after moderate caloric restriction or gastric bypass.

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Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Gastric bypass

Subjects with planned gastric bypass surgery are followed-up in regard of resting metabolic rate.

Group Type OTHER

Gastric bypass

Intervention Type PROCEDURE

Subjects with a planned gastric bypass surgery are followed-up for resting metabolic rate.

Caloric restriction

Caloric restriction calculated by an online weight management program (based on subject's starting weight, start BMI, age, target weight and time span). Subjects are followed-up in regard to resting metabolic rate.

Group Type OTHER

Caloric restriction

Intervention Type BEHAVIORAL

Subjects receive caloric restriction as calculated by an online weight management program and are followed-up for resting metabolic rate.

Interventions

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Gastric bypass

Subjects with a planned gastric bypass surgery are followed-up for resting metabolic rate.

Intervention Type PROCEDURE

Caloric restriction

Subjects receive caloric restriction as calculated by an online weight management program and are followed-up for resting metabolic rate.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* BMI ≥30 kg/m2

Exclusion Criteria

* Marked weight reduction in the last 2 years (\>5% of initial body weight)
* Recent extreme fasting (during the last month)
* Manifest eating disorders (assignment to a specialist for eating disorders)
* Severe psychiatric disorders requiring treatment
* Pregnancy, lactation

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No