Studies of Biological Changes Related to Weight Loss After Gastric Bypass Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

13 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-07-31

Brief Summary

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Weight loss achieved by dieting induces multiple changes. These changes include a decrease in metabolic rate (the rate in which the body burns its calories), an increase in appetite and other physiological and hormonal changes that may be the cause of failure in dieting. Many of these parameters that have never been evaluated when weight is lost after gastric bypass surgery will be tested in this study.

Detailed Description

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While gastric bypass surgery (GBS) is known to be highly effective in achieving significant weight loss, it is also associated with other biologic changes that occur in the body when weight is lost. In this study, subjects undergoing gastric bypass surgery will be followed throughout the weight loss period. They will undergo four detailed medical evaluations to assess changes in several biological systems that occur in the body when weight is lost.

The initial assessment will be performed before the surgery (testing period 1). After surgery is completed, subjects will attend clinic visits at the Rockefeller University outpatient clinic. During these visits, weight and leptin levels will be monitored. Two additional assessments will be performed during weight loss, when subjects lose 10% and 20% of their initial weight (testing periods 2 and 3 respectively). A final evaluation will be performed after weight is stabilized, about 18 months after the surgery is completed (testing period 4). Each testing period will be performed over a 2 week period in an inpatient setting at the Rockefeller University Hospital. During testing periods subjects will undergo a series of metabolic, behavioral, hormonal, immune and molecular tests to evaluate changes that occur in the body after weight loss. Subjects will receive monetary compensation for participating in the study.

Conditions

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Obesity Morbid Obesity Weight Loss

Keywords

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weight loss surgery gastric bypass surgery

Study Design

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Study Time Perspective

PROSPECTIVE

Interventions

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Gastric Bypass Surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18 - 65 years old
* Subjects approved for gastric bypass surgery

Exclusion Criteria

* Subjects not approved for gastric bypass surgery

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Jeffrey M. Friedman, MD

Role: PRINCIPAL_INVESTIGATOR

Rockefeller University

Locations

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St. Luke's Obesity Research Center, NY NY 10023 and New York Hospital

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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JFN 0385

Identifier Type: -

Identifier Source: org_study_id