Cognitive Impairment, Obesity, and the Effects of Bariatric Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

9500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2028-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Study is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Change in Cognitive Function in Obese Patients After Bariatric Surgery - an Observational Study

NCT01554228

Obesity Bariatric Surgery

COMPLETED

Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle

NCT02085369

Obesity, Morbid

UNKNOWN

Cognitive Effects of Bariatric Surgery

NCT00671775

Bariatric Surgery Patients

COMPLETED

Psychological Preparation Prior to Bariatric Surgery

NCT01670331

Obesity Psychological Disorders

COMPLETED NA

Brain Gut Axis Changes After Bariatric Surgery and Their Relationship to Weight Loss

NCT04429386

Obesity Bariatric Surgery Candidate

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients with morbid obesity have shown to be at increased risk for memory loss and cognitive decline. Obesity and high-fat diets have been associated with deficits in learning, memory, and executive functioning. Bariatric surgery results in significant weight loss for patients and helps resolve obesity-related comorbidities such as diabetes and high blood pressure. Interestingly, bariatric surgery has shown promise in improving some aspects of cognitive function and improved memory. (3-1) Obesity affects brain structure, more specifically the grey and white matter, likely in part by reducing oxygen flow to the various regions in the brain. Studies have shown a correlation between BMI and cerebral blood flow velocity (CBFV), where higher BMI is associated with lower CBFV. Although it is not clear how exactly obesity plays a role in the brain's structural and functional changes, observations revealed compromised grey and white matter integrity, its fiber connectivity or cortical atrophy and metabolic alterations. (2)

Few studies exist on the impact of bariatric surgery on cognition. Some studies have shown that patients with obesity who underwent bariatric surgery had memory and cognitive improvement compared to those who had not undergone surgery. (4) Thus, the investigators hope to add to our understanding of how bariatric surgery can improve cognitive decline and to potentially offer surgery to more patients with baseline cognitive impairment and to improve cognitive function overall for patients with obesity. More longitudinal studies need to be done to connect bariatric surgery effects with cognitive decline, specifically memory.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity, Morbid Bariatric Surgery Candidate

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Surgery

Patients scheduled for or have already completed Weight Loss Surgery at UC Davis Medical Center

Surgery

Intervention Type BEHAVIORAL

Study subjects scheduled for or have already completed weight loss surgery and have already completed psychological screening as part of their pre-surgery work up

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Surgery

Study subjects scheduled for or have already completed weight loss surgery and have already completed psychological screening as part of their pre-surgery work up

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Cognitive impairment/decline, memory impairment/loss, or Alzheimer's disease or dementia and bariatric surgery • Cognitive impairment/decline, memory impairment/loss, or Alzheimer's disease or dementia and obesity, and no bariatric surgery history

Exclusion Criteria

* Patients without a history of memory impairment/loss, bariatric surgery, or obesity

* Patients outside of University of California Davis Health System
* Patients unable to provide consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No