Transfacial Sutures Versus Stapler for Mesh Fixation in Laparoscopic Ventral Hernia Repair

NCT ID: NCT00773851

Last Updated: 2023-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-04-30

Study Completion Date

2008-10-31

Brief Summary

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Hernia of the abdominal wall occur frequently after various surgical procedures of the abdomen and are increasingly performed by laparoscopic means. Different mesh fixation techniques are applied, but the influence of mesh fixation on shrinkage is not known in human patients. Therefore, mesh shrinkage was assessed using two different techniques for fixation.

Detailed Description

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Ventral hernia repair is increasingly performed by laparoscopic means. While mesh ingrowth and shrink-age has been analysed in the experimental setting, there is scarce data available in humans. In addition, different mesh fixation techniques are applied, but the influence of mesh fixation on shrinkage is not known in human patients.

Mesh shrinkage is assessed using two different techniques for fixation.

Blinded randomized trial using a Parietene composite mesh for laparoscopic ventral hernia repair. Patients with ventral hernias of no larger than 8 cm were assigned to either mesh fixation using transfacial nonabsorbable sutures or titan tacks. Primary endpoint was mesh migration, secondary endpoints were mesh shrinkage, surgical morbidity and pain.

Conditions

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Ventral Hernia Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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A

transfacial sutures

Group Type OTHER

mesh fixation by transfacial sutures

Intervention Type PROCEDURE

mesh fixation by transfacial sutures

B

staples

Group Type OTHER

mesh fixation by staples

Intervention Type PROCEDURE

mesh fixation by staples

Interventions

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mesh fixation by transfacial sutures

mesh fixation by transfacial sutures

Intervention Type PROCEDURE

mesh fixation by staples

mesh fixation by staples

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with incisional hernia smaller than 8cm in diameter
* obtained informed consent

Exclusion Criteria

* Pregnancy
* Residual intraperitoneal mesh
* contaminated abdominal cavity
* longterm use of corticosteroids and other immunosuppressive agents
* bodymass index \> 45
* general contradictions for laparoscopy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sofradim Production

INDUSTRY

Sponsor Role collaborator

Medtronic - MITG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guido1 Beldi, MD

Role: PRINCIPAL_INVESTIGATOR

Bern University Hospital

Locations

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Dep. of Visceral and Transplantsurgery, Bern University Hospital

Bern, , Switzerland

Site Status

Countries

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Switzerland

References

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Heniford BT, Park A, Ramshaw BJ, Voeller G. Laparoscopic repair of ventral hernias: nine years' experience with 850 consecutive hernias. Ann Surg. 2003 Sep;238(3):391-9; discussion 399-400. doi: 10.1097/01.sla.0000086662.49499.ab.

Reference Type BACKGROUND
PMID: 14501505 (View on PubMed)

Borrazzo EC, Belmont MF, Boffa D, Fowler DL. Effect of prosthetic material on adhesion formation after laparoscopic ventral hernia repair in a porcine model. Hernia. 2004 May;8(2):108-12. doi: 10.1007/s10029-003-0181-6. Epub 2003 Nov 21.

Reference Type BACKGROUND
PMID: 14634842 (View on PubMed)

van't Riet M, de Vos van Steenwijk PJ, Kleinrensink GJ, Steyerberg EW, Bonjer HJ. Tensile strength of mesh fixation methods in laparoscopic incisional hernia repair. Surg Endosc. 2002 Dec;16(12):1713-6. doi: 10.1007/s00464-001-9202-7. Epub 2002 Jul 8.

Reference Type BACKGROUND
PMID: 12098028 (View on PubMed)

Winslow ER, Diaz S, Desai K, Meininger T, Soper NJ, Klingensmith ME. Laparoscopic incisional hernia repair in a porcine model: what do transfixion sutures add? Surg Endosc. 2004 Mar;18(3):529-35. doi: 10.1007/s00464-003-8519-9. Epub 2004 Feb 2.

Reference Type BACKGROUND
PMID: 14752650 (View on PubMed)

LeBlanc KA. The critical technical aspects of laparoscopic repair of ventral and incisional hernias. Am Surg. 2001 Aug;67(8):809-12.

Reference Type BACKGROUND
PMID: 11510590 (View on PubMed)

Carbajo MA, Martp del Olmo JC, Blanco JI, Toledano M, de la Cuesta C, Ferreras C, Vaquero C. Laparoscopic approach to incisional hernia. Surg Endosc. 2003 Jan;17(1):118-22. doi: 10.1007/s00464-002-9079-0. Epub 2002 Oct 29.

Reference Type BACKGROUND
PMID: 12399849 (View on PubMed)

Chelala E, Gaede F, Douillez V, Dessily M, Alle JL. The suturing concept for laparoscopic mesh fixation in ventral and incisional hernias: preliminary results. Hernia. 2003 Dec;7(4):191-6. doi: 10.1007/s10029-003-0143-z. Epub 2003 Jun 13.

Reference Type BACKGROUND
PMID: 12811619 (View on PubMed)

LeBlanc KA. Tack hernia: a new entity. JSLS. 2003 Oct-Dec;7(4):383-7.

Reference Type BACKGROUND
PMID: 14626408 (View on PubMed)

Leber GE, Garb JL, Alexander AI, Reed WP. Long-term complications associated with prosthetic repair of incisional hernias. Arch Surg. 1998 Apr;133(4):378-82. doi: 10.1001/archsurg.133.4.378.

Reference Type BACKGROUND
PMID: 9565117 (View on PubMed)

Schumpelick V, Klinge U. Prosthetic implants for hernia repair. Br J Surg. 2003 Dec;90(12):1457-8. doi: 10.1002/bjs.4385. No abstract available.

Reference Type BACKGROUND
PMID: 14648721 (View on PubMed)

Other Identifiers

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KEK_11/05

Identifier Type: -

Identifier Source: org_study_id

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