GORE VIABAHN Endoprosthesis Versus Percutaneous Transluminal Angioplasty (PTA) to Revise AV Grafts in Hemodialysis

NCT ID: NCT00737672

Last Updated: 2014-10-21

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

293 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Study Completion Date

2013-06-30

Brief Summary

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The objective of the study is to establish efficacy and safety of the GORE VIABAHN® Endoprosthesis with PROPATEN Bioactive Surface when used to revise arteriovenous (AV) prosthetic grafts at the venous anastomosis in the maintenance or re-establishment of vascular access for hemodialysis.

Detailed Description

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The primary effectiveness hypothesis is to demonstrate that the GORE VIABAHN® Endoprosthesis with PROPATEN Bioactive Surface will extend the period of target lesion primary patency as compared to PTA.

The primary safety hypothesis is to demonstrate that the proportion of subjects remaining free from major device, procedure, and treatment site-related adverse events through 30 days post-procedure in the GORE® VIABAHN® Device group is not inferior to that of the PTA group.

Conditions

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Renal Failure Hemodialysis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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VIABAHN Treatment Group

Use of GORE VIABAHN Endoprosthesis with PROPATEN Bioactive Surface to revise arteriovenous (AV) prosthetic grafts at the venous anastomosis in the maintenance or re-establishment of vascular access for hemodialysis as compared to Comparator Arm

Group Type EXPERIMENTAL

GORE VIABAHN Endoprosthesis with PROPATEN Bioactive Surface

Intervention Type DEVICE

Deployment of investigational stent graft at the venous anastomosis

PTA Treatment Group

Percutaneous Transluminal Angioplasty (PTA) in arteriovenous (AV) prosthetic grafts at the venous anastomosis in the maintenance or re-establishment of vascular access for hemodialysis as compared to Experimental Arm

Group Type ACTIVE_COMPARATOR

Percutaneous Transluminal Angioplasty

Intervention Type PROCEDURE

Percutaneous Transluminal Angioplasty at the venous anastomosis

Interventions

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GORE VIABAHN Endoprosthesis with PROPATEN Bioactive Surface

Deployment of investigational stent graft at the venous anastomosis

Intervention Type DEVICE

Percutaneous Transluminal Angioplasty

Percutaneous Transluminal Angioplasty at the venous anastomosis

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Hemodialysis patient with a dysfunctional or thrombosed forearm or upper arm prosthetic vascular access graft.
* The target lesion starts less than or equal to 30 mm from the venous anastomosis.
* The target lesion has \> 50% stenosis as measured per protocol.
* The patient has a maximum of one secondary stenosis.

Exclusion Criteria

* The age of the hemodialysis access graft is less than or equal to 30 days old from the date of the study procedure.
* The patient has undergone an intervention (surgical or percutaneous) of the vascular access circuit less than or equal to 30 days from the date of the study procedure.
* The secondary lesion is an occlusion.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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W.L.Gore & Associates

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tom Vesely, MD

Role: STUDY_DIRECTOR

Vascular Access Center; Frontenac, MO

Locations

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Birmingham, Alabama, United States

Site Status

Fresno, California, United States

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Inglewood, California, United States

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Oceanside, California, United States

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Riverside, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Francisco, California, United States

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New Haven, Connecticut, United States

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Jacksonville, Florida, United States

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Albany, Georgia, United States

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Chicago, Illinois, United States

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Des Moines, Iowa, United States

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Louisville, Kentucky, United States

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Baltimore, Maryland, United States

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New Brighton, Minnesota, United States

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Saint Paul, Minnesota, United States

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Cincinnati, Ohio, United States

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Cincinnati, Ohio, United States

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Dayton, Ohio, United States

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Portland, Oregon, United States

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Philadelphia, Pennsylvania, United States

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Charleston, South Carolina, United States

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Greenville, South Carolina, United States

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Beaumont, Texas, United States

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Houston, Texas, United States

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Norfolk, Virginia, United States

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Winchester, Virginia, United States

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Bellevue, Washington, United States

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Spokane, Washington, United States

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Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

References

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Mohr BA, Sheen AL, Roy-Chaudhury P, Schultz SR, Aruny JE; REVISE Investigators. Clinical and Economic Benefits of Stent Grafts in Dysfunctional and Thrombosed Hemodialysis Access Graft Circuits in the REVISE Randomized Trial. J Vasc Interv Radiol. 2019 Feb;30(2):203-211.e4. doi: 10.1016/j.jvir.2018.12.006.

Reference Type DERIVED
PMID: 30717951 (View on PubMed)

Other Identifiers

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G070069

Identifier Type: OTHER

Identifier Source: secondary_id

AVR 06-01

Identifier Type: -

Identifier Source: org_study_id

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