Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

391 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-08-31

Study Completion Date

2009-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID), non-Helicobacter pylori (HP) bleeding ulcer patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Helicobacter Pylori and the Long-term Risk of Peptic Ulcer Bleeding

NCT01591486

Bacterial Infection Due to Helicobacter Pylori (H. Pylori) Peptic Ulcer Bleeding

COMPLETED

Influence of Oral Hp Infection and Oral Related Factors on Gastric Hp Infection and Eradication Therapy

NCT05455372

Helicobacter Pylori Infection

UNKNOWN NA

Helicobacter Pylori and Proton Pump Inhibitor

NCT02449941

Helicobacter Infections

COMPLETED

China Survey of Peptic Ulcer Bleeding

NCT01241266

Peptic Ulcer Hemorrhage

COMPLETED

Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study

NCT02152904

Peptic Ulcer Bleeding

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Peptic Ulcer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Non NSAID non-Hp

Patient of history of peptic ulcer bleeding with Hp-ve and without prior history of taking NSAID or Aspirin within 30 days

No interventions assigned to this group

Helicobacter pylori +ve

Patient with Hp+ve at peptic ulcer bleeding

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient has non-NSAID (non-steroidal anti-inflammatory drugs), non-Helicobacter pylori bleeding peptic ulcer
* Age \> 18 years old
* Informed consent

Exclusion Criteria

* Concommitant use of high dose steroid or warfarin
* New start on non-steroidal anti-inflammatory drugs or aspirin or COX2 inhibitors
* Renal failure (serum creatinine \> 200umol/l)
* Previous gastric surgery
* Oesophagitis, esophageal varices
* Terminal illness or malignancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No