Helicobacter Pylori and Proton Pump Inhibitor

NCT ID: NCT02449941

Last Updated: 2016-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2016-12-31

Brief Summary

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The purpose of this study is to know the distribution of HP in stomach before use of PPI, during use of PPI, and after stop of PPI.

Detailed Description

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Endoscopy and biopsy will be performed to investigate the distrubition of HP before, during, and after using PPI.

Conditions

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Helicobacter Infections

Keywords

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Stomach Neoplasms proton pump inhibitor endoscopic submucosal dissection Helicobacter pylori Gastritis, Atrophic

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Helicobacter pylori(HP) positive

Participants who are diagnosed with Helicobacter Pylori infection through ESD(endoscopic submucosal dissection) will be treated with PPI (proton pump inhibitor).

PPI (proton pump inhibitor)

Intervention Type DRUG

1. Pre ESD (endoscopic submucosal dissection)

* Assessment atrophy and metaplasia in stomach, Check Helicobacter pylori
* Use of PPI for 2 months
2. Post ESD 1 (After 2 months)

* Assess the distribution of helicobacter pylori after using PPI.
* Stop of PPI
3. Post ESD 2 (After 4 months)

* Assess the distribution of helicobacter pylori after stop of PPI.

Interventions

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PPI (proton pump inhibitor)

1. Pre ESD (endoscopic submucosal dissection)

* Assessment atrophy and metaplasia in stomach, Check Helicobacter pylori
* Use of PPI for 2 months
2. Post ESD 1 (After 2 months)

* Assess the distribution of helicobacter pylori after using PPI.
* Stop of PPI
3. Post ESD 2 (After 4 months)

* Assess the distribution of helicobacter pylori after stop of PPI.

Intervention Type DRUG

Other Intervention Names

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pantoprazole, lansoprazole, dexlansoprazole, rabeprazole

Eligibility Criteria

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Inclusion Criteria

1. Patients who are indicated to endoscopic resection due to gastric neoplasm
2. Aged between 19 to 65 years
3. Informed consent

Exclusion Criteria

1. Previous history of HP eradication
2. Previous history of PPI use within 6 months
3. No HP infection
Minimum Eligible Age

19 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ji Yong Ahn

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ji Yong Ahn, Professor

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

Locations

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Asan Medical Center

Seoul, Songpa-gu, South Korea

Site Status

Countries

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South Korea

References

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Gong EJ, Kim DH, Ahn JY, Na HK, Jung KW, Lee JH, Choi KD, Song HJ, Lee GH, Jung HY, Park Y, Kim MJ. Effects of Proton Pump Inhibitor on the Distribution of Helicobacter pylori and Associated Gastritis in Patients with Gastric Atrophy. Digestion. 2020;101(3):279-286. doi: 10.1159/000499424. Epub 2019 May 8.

Reference Type DERIVED
PMID: 31067538 (View on PubMed)

Other Identifiers

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2014-0341

Identifier Type: -

Identifier Source: org_study_id