Magnetic Resonance Imaging at Different Levels of Magnetic Intensity

NCT ID: NCT00001619

Last Updated: 2017-07-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 497 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1996-11-05
• Study Completion Date: 2011-07-20

Brief Summary

Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a substance called gadolinium. Gadolinium works by brightening areas of the magnetic resonance image, thereby improving the contrast.

In this study researchers will use magnetic resonance imaging and contrast substances, like gadolinium, on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI.

Detailed Description

Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies will be conducted in the MRI systems located at the NIH. These studies may involve the intravenous administration of commercially available MR contrast media and exercise. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and RF coils on human subjects and will provide essential ground work for specific patient protocols.

Conditions

Cardiovascular Disease; Healthy

Eligibility Criteria

Inclusion Criteria

Any normal volunteer greater than or equal to 18 who is capable of giving informed consent.

Exclusion Criteria

A subject will be excluded if he/she has a contraindication to MR scanning such as:

1. Brain aneurysm clip

2. Implanted neural stimulator

3. Implanted cardiac pacemaker or defibrillator

4. Cochlear or ear implant

5. Ocular foreign body (e.g. metal shavings)

6. Insulin pump

7. Pregnant women (when uncertain, subject will undergo urine or blood testing).

8. Claustrophobia

9. Any condition in the Principal Investigator's judgement which present unnecessary risk

1. Lactating Women

2. Renal or hepatic disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: lead

Locations

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, United States

Countries

United States

References

Mattay VS, Weinberger DR, Barrios FA, Sobering GS, Kotrla KJ, van Gelderen P, Duyn JH, Sexton RH, Moonen CT, Frank JA. Brain mapping with functional MR imaging: comparison of gradient-echo--based exogenous and endogenous contrast techniques. Radiology. 1995 Mar;194(3):687-91. doi: 10.1148/radiology.194.3.7862963.

Reference Type: BACKGROUND

PMID: 7862963 (View on PubMed)

Niendorf HP, Dinger JC, Haustein J, Cornelius I, Alhassan A, Clauss W. Tolerance data of Gd-DTPA: a review. Eur J Radiol. 1991 Jul-Aug;13(1):15-20. doi: 10.1016/0720-048x(91)90049-2.

Reference Type: BACKGROUND

PMID: 1889423 (View on PubMed)

Frank JA, Mattay VS, Duyn J, Sobering G, Barrios FA, Zigun J, Sexton R, Kwok P, Woo J, Moonen C, et al. Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentetate-dimeglumine-enhanced dynamic magnetic resonance imaging. Invest Radiol. 1994 Jun;29 Suppl 2:S157-60. doi: 10.1097/00004424-199406001-00052. No abstract available.

Reference Type: BACKGROUND

PMID: 7928216 (View on PubMed)

Other Identifiers

97-H-0026

Identifier Type: -

Identifier Source: secondary_id

970026

Identifier Type: -

Identifier Source: org_study_id