Clinical Trials Updated in 2025

NCT06991322 | RECRUITING | NA

30 Participants

Self-Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD) (SERRA-I Study)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-18

Completion: 2026-12-31

Conditions

Coronary Microvascular Dysfunction Coronary Microvascular Disease

Interventions

DEVICE

No Results Yet

NCT06991062 | RECRUITING | NA

100 Participants

Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-02-19

Completion: 2026-12-01

Conditions

Smoking

Interventions

PROCEDURE

No Results Yet

NCT06989853 | RECRUITING | EARLY_PHASE1

40 Participants

Methamphetamine and Troriluzole

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-08-25

Completion: 2029-02-28

Conditions

Methamphetamine Use Disorder

Interventions

DRUG

No Results Yet

NCT06988553 | COMPLETED | PHASE1

45 Participants

A Phase Ib Study of AZD5004 in Chinese Participants With Overweight/Obesity With or Without Type 2 Diabetes Mellitus

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-17

Completion: 2025-11-28

Conditions

Obesity or Overweight Type 2 Diabetes

Interventions

DRUG

No Results Yet

NCT06982235 | RECRUITING

238 Participants

Stone and Laser Therapies Post-Market Study (SALT)

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-30

Completion: 2029-02-28

Conditions

Benign Prostate Hypertrophy(BPH) Renal Calculi Ureteral Stones, Kidney Stones Calculi, Urinary Urinary Tract Procedure

Interventions

DEVICE

No Results Yet

NCT06981832 | RECRUITING | NA

70 Participants

Physical Activity for Haemodialysis Patients: Evaluation of Personalised Support by an Adapted Physical Activity Teacher and an Advanced Practice Nurse

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-10-28

Completion: 2027-10-31

Conditions

Hemodialysis

Interventions

BEHAVIORAL

No Results Yet

NCT06963801 | RECRUITING | NA

100 Participants

DBT-P Treatment Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-06

Completion: 2026-12-31

Conditions

Emotion Dysregulation

Interventions

BEHAVIORAL

No Results Yet

NCT06959706 | RECRUITING | PHASE1

50 Participants

Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-05-07

Completion: 2026-09-30

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT06959264 | COMPLETED | NA

70 Participants

Effect of Virtual Reality Goggles on Anxiety, Comfort and Complications in Patients Undergoing Transrectal Ultrasound-guided Prostate Biopsy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-04-28

Completion: 2025-12-15

Conditions

Prostate Biopsy

Interventions

OTHER

No Results Yet

NCT06957028 | RECRUITING | NA

6000 Participants

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-05-27

Completion: 2027-11-27

Conditions

Gestational Diabetes Mellitus in Pregnancy

Interventions

OTHER

No Results Yet

NCT06951711 | RECRUITING | PHASE3

274 Participants

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-13

Completion: 2026-11-02

Conditions

Bipolar Disorder Type I With Mania or Mania With Mixed Features

Interventions

DRUG OTHER

No Results Yet

NCT06943872 | RECRUITING | PHASE3

630 Participants

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-11

Completion: 2029-09-30

Conditions

Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma

Interventions

DRUG

No Results Yet

NCT06943859 | RECRUITING | PHASE2

50 Participants

Ketamine for Opioid Use Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2026-01-31

Completion: 2028-08-31

Conditions

Opioid Use Disorder

Interventions

DRUG

No Results Yet

NCT06942702 | NOT_YET_RECRUITING | NA

44 Participants

Efficacy of Genicular Block on Total Knee Arthroplasty Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-12-20

Completion: 2026-10-20

Conditions

Total Knee Anthroplasty Genicular Nerves Block

Interventions

DRUG

No Results Yet

NCT06936943 | RECRUITING | PHASE2

14 Participants

ONO-4538 Study in Patients With Richter's Transformation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-11-19

Completion: 2029-07-31

Conditions

Richter's Transformation

Interventions

DRUG

No Results Yet

NCT06934967 | RECRUITING | PHASE3

12 Participants

Study to Assess the Pharmacokinetics, Safety, and Tolerability of Iptacopan in Pediatric PNH Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-10-28

Completion: 2031-11-19

Conditions

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Interventions

DRUG

No Results Yet

NCT06932809 | RECRUITING | EARLY_PHASE1

90 Participants

Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-05-09

Completion: 2030-04-30

Conditions

Tauopathies

Interventions

DRUG DIAGNOSTIC_TEST BEHAVIORAL

No Results Yet

NCT06932302 | RECRUITING | NA

24 Participants

At-Home Neuromodulation for Female Sexual Dysfunction

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-10-15

Completion: 2027-10-31

Conditions

Female Sexual Dysfunction

Interventions

DEVICE

No Results Yet

NCT06929273 | RECRUITING | PHASE3

450 Participants

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-07-18

Completion: 2028-06-13

Conditions

Bipolar Disorder Type I With Mania

Interventions

DRUG

No Results Yet

NCT06927973 | COMPLETED | NA

30 Participants

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-05-30

Completion: 2025-12-19

Conditions

Chest Pain Shortness of Breath

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06925022 | ACTIVE_NOT_RECRUITING | NA

30 Participants

Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: The ADVICE Protocol Study (Phase 1)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2024-12-15

Completion: 2025-06-30

Conditions

Multiple Sclerosis (MS) - Relapsing-remitting

Interventions

OTHER

No Results Yet

NCT06912724 | RECRUITING

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2025-04-01

Completion: 2025-08-31

Conditions

Healthy Healthy Adult

No Results Yet

NCT06899022 | RECRUITING | NA

138 Participants

Attention and Eye Movement in Parkinson's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-09-22

Completion: 2028-02-29

Conditions

Essential Tremor Parkinson's Disease (PD)

Interventions

OTHER

No Results Yet

NCT06891755 | RECRUITING | NA

250 Participants

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-07-15

Completion: 2027-09-30

Conditions

COPD Emphysema

Interventions

DEVICE OTHER

No Results Yet

NCT06888817 | RECRUITING | PHASE3

408 Participants

Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-06-19

Completion: 2028-07-31

Conditions

Radiation Necrosis High Grade Glioma (III or IV) Brain Metastasases Radiation Toxicity Radiation Effect Radiation Injury Radiation Injuries

Interventions

DRUG

No Results Yet

NCT06887192 | RECRUITING | PHASE2

300 Participants

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-08-15

Completion: 2027-02-28

Conditions

Psychosis Associated With Alzheimer's Disease

Interventions

DRUG

No Results Yet

NCT06883240 | RECRUITING

40 Participants

An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2025-04-29

Completion: 2026-11-01

Conditions

Von Willebrand Disease, Type 3

Interventions

DRUG

No Results Yet

NCT06873581 | RECRUITING | PHASE3

266 Participants

Pivotal Study of Voro Urologic Scaffold

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-04-18

Completion: 2027-02-01

Conditions

Radical Prostatectomy Stress Urinary Incontinence (SUI)

Interventions

DEVICE

No Results Yet

NCT06870383 | RECRUITING | NA

66 Participants

Erector Spinae Block Versus Combined Pecto-intercostal and Recto-intercostal Fascial Plane Block in Cardiac Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-03-20

Completion: 2026-03-20

Conditions

Erector Spinae Plane Block Pecto-intercostal Fascial Plane Block Recto-intercostal Fascial Plane Block Cardiac Surgery

Interventions

DRUG

No Results Yet

NCT06863402 | RECRUITING | PHASE2

32 Participants

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2026-02-15

Completion: 2029-04-01

Conditions

Richter Syndrome Diffuse Large B-Cell Lymphoma Chronic Lymphocytic Leukemia

Interventions

PROCEDURE DRUG BIOLOGICAL OTHER

No Results Yet

NCT06863337 | RECRUITING | NA

100 Participants

Glucose Pattern in Infertile Women Receiving Assisted Reproduction Using Continuous Glucose Monitoring

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-03-26

Completion: 2026-06-30

Conditions

Infertility Female

Interventions

DEVICE

No Results Yet

NCT06850805 | RECRUITING | PHASE3

84 Participants

Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-07-28

Completion: 2028-03-31

Conditions

Chronic Rhinosinusitis Without Nasal Polyps

Interventions

DRUG

No Results Yet

NCT06846099 | COMPLETED | PHASE1

69 Participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Efficacy and Indications of RP903

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-12-07

Completion: 2025-05-30

Conditions

Ovarian Cancer Cervical Cancer Endometrial Cancer Breast Cancer Solid Tumor Cancer

Interventions

DRUG

No Results Yet