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Efficacy of Genicular Block on Total Knee Arthroplasty Surgery

NCT ID: NCT06942702

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-20

Study Completion Date

2026-12-20

Brief Summary

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The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:

1. Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block?
2. Does opioid consumption decrease in patients who underwent geniculate block?

Researchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.

Detailed Description

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Patients scheduled for knee arthroplasty will be randomly assigned into two groups. One group will receive a genicular nerve block prior to surgery without the administration of general anesthesia, while the other group will not undergo any interventional procedure. The genicular nerve block will be administered in three quadrants around the knee, with each injection consisting of 5 mL of 0.25% Marcaine. All injections will be performed by investigator MA. Patient assessments will be conducted by investigator MO. Postoperative intravenous analgesia will be provided to both groups.

Conditions

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Total Knee Anthroplasty Genicular Nerves Block

Keywords

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total knee arthroplasty genicular block postoperative pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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Genicular block group

this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Group Type ACTIVE_COMPARATOR

Genicular blocks (bupivakain)

Intervention Type DRUG

Genicular block is a regional analgesic technique performed with USG

Patient Control Analgesia (PCA) Morphine group

Intervention Type DRUG

this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Paracetamol (acetaminophen) + Diclofenac Sodium

Intervention Type DRUG

All patients are given paracetamol (3x1000 mg) and diclofenac (if needed)

patients only given PCA-morfin postoperatively

this group consists of the patients given morfin with PCA, paracetamol 3x1000 mg and diclofenac (if needed)

Group Type ACTIVE_COMPARATOR

Patient Control Analgesia (PCA) Morphine group

Intervention Type DRUG

this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Paracetamol (acetaminophen) + Diclofenac Sodium

Intervention Type DRUG

All patients are given paracetamol (3x1000 mg) and diclofenac (if needed)

Interventions

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Genicular blocks (bupivakain)

Genicular block is a regional analgesic technique performed with USG

Intervention Type DRUG

Patient Control Analgesia (PCA) Morphine group

this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Intervention Type DRUG

Paracetamol (acetaminophen) + Diclofenac Sodium

All patients are given paracetamol (3x1000 mg) and diclofenac (if needed)

Intervention Type DRUG

Other Intervention Names

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PCA-M

Eligibility Criteria

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Inclusion Criteria

* Scheduled for unilateral and primary total knee arthroplasty
* Older than 18 years of age

Exclusion Criteria

* Younger than 18 years
* Bilateral knee arthroplasty
* Revision case of knee arthroplasty
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mersin University

OTHER

Sponsor Role lead

Responsible Party

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Mustafa Azizoğlu

Associated Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mustafa Azizoglu, Associated Professor

Role: PRINCIPAL_INVESTIGATOR

Mersin university Faculty of Medicine, Department of Anesthesiology and Reanimation

Central Contacts

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Mustafa Azizoglu, Associated Professor

Role: CONTACT

Phone: +90 5325667061

Email: [email protected]

Mervenur Ozturk, Resident Doctor

Role: CONTACT

Phone: +90 5525345189

Email: [email protected]

References

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Wang T, Leng YF, Zhang Y, Kang YQ, Xue X, Zhang Y. [Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1130-5. Chinese.

Reference Type BACKGROUND
PMID: 21609599 (View on PubMed)

Other Identifiers

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MersinUgenicular

Identifier Type: -

Identifier Source: org_study_id