Clinical Trials

Showing trials with last updates posted in 2025.

NCT05444504 | RECRUITING | NA
100 Participants

Effectiveness and Acceptability of Insertable Devices for Obstetric Fistula Management

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-04-15
Completion: 2026-10-01
Conditions
Obstetric Fistula Fistula Fistula, Urinary Fistula, Vaginal
Interventions
DEVICE
No Results Yet
NCT05431686 | COMPLETED | NA
14 Participants

Group Visits for High Risk Type 1 Diabetes (T1D)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-16
Completion: 2025-07-01
Conditions
Type 1 Diabetes
Interventions
BEHAVIORAL
NCT05423210 | RECRUITING | EARLY_PHASE1
12 Participants

Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-25
Completion: 2027-08-31
Conditions
Glioblastoma Multiforme
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05420948 | RECRUITING | PHASE2
30 Participants

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-17
Completion: 2026-12-01
Conditions
Head and Neck Cancer Head and Neck Squamous Cell Carcinoma Head and Neck Neoplasms Head Cancer Throat Carcinoma
Interventions
DRUG
No Results Yet
NCT05418764 | RECRUITING | NA
70 Participants

Effect of Validated Skills Simulation With the Miya Model

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-27
Completion: 2026-01-31
Conditions
Vaginal Hysterectomy
Interventions
OTHER
No Results Yet
NCT05417594 | RECRUITING | PHASE1/PHASE2
695 Participants

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-24
Completion: 2027-08-11
Conditions
Advanced Solid Malignancies
Interventions
DRUG
No Results Yet
NCT05416333 | RECRUITING | EARLY_PHASE1
15 Participants

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-12
Completion: 2026-05-31
Conditions
Central Centrifugal Cicatricial Alopecia
Interventions
DRUG OTHER
No Results Yet
NCT05407324 | ACTIVE_NOT_RECRUITING | PHASE2
279 Participants

Dazucorilant in Patients With Amyotrophic Lateral Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-15
Completion: 2026-09-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG OTHER
No Results Yet
NCT05391672 | RECRUITING | NA
30 Participants

Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-09
Completion: 2026-03-19
Conditions
ACL Injury ACL Augmentation
Interventions
PROCEDURE
No Results Yet
NCT05382338 | RECRUITING | PHASE3
225 Participants

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-02-20
Completion: 2027-12-20
Conditions
Childhood Medulloblastoma
Interventions
PROCEDURE DRUG OTHER RADIATION
No Results Yet
NCT05380453 | ACTIVE_NOT_RECRUITING | PHASE3
151 Participants

Efficacy and Safety of Secukinumab in Patients With New Onset of Giant Cell Arteritis Who Are in Clinical Remission

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-21
Completion: 2026-01-29
Conditions
Giant Cell Arteritis
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05379166 | ACTIVE_NOT_RECRUITING | PHASE2
33 Participants

Venetoclax and Azacitidine for Treatment of Therapy Related or Secondary Myelodysplastic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-23
Completion: 2026-01-15
Conditions
Secondary Myelodysplastic Syndrome Therapy-Related Myelodysplastic Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT05352672 | ACTIVE_NOT_RECRUITING | PHASE3
1546 Participants

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-14
Completion: 2026-03-16
Conditions
Melanoma
Interventions
DRUG
No Results Yet
NCT05350072 | ACTIVE_NOT_RECRUITING | PHASE3
276 Participants

Two-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-28
Completion: 2025-05-07
Conditions
Sjogren Syndrome
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05349214 | ACTIVE_NOT_RECRUITING | PHASE3
506 Participants

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-04
Completion: 2025-05-13
Conditions
Sjogren Syndrome
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05347095 | ACTIVE_NOT_RECRUITING | PHASE3
288 Participants

A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-27
Completion: 2027-03-25
Conditions
Fistulizing Crohns Disease Perianal Crohns Disease
Interventions
DRUG
No Results Yet
NCT05342753 | COMPLETED | NA
22 Participants

Safety and Effectiveness of Restylane® Kysse for Lip Augmentation in Chinese Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-13
Completion: 2024-10-25
Conditions
Lip Augmentation
Interventions
DEVICE
NCT05337618 | RECRUITING | PHASE2
72 Participants

Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-12-16
Completion: 2026-09-01
Conditions
Traumatic Brain Injury
Interventions
DIAGNOSTIC_TEST COMBINATION_PRODUCT
No Results Yet
NCT05320367 | NOT_YET_RECRUITING | PHASE1/PHASE2
80 Participants

A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2026-09-30
Completion: 2027-10-31
Conditions
Cannabis
Interventions
DRUG
No Results Yet
NCT05318924 | COMPLETED | PHASE1/PHASE2
26 Participants

Effects of Ghrelin Administration on Dopamine and Effort

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-21
Completion: 2024-08-06
Conditions
Major Depressive Disorder
Interventions
DRUG OTHER
No Results Yet
NCT05317416 | ACTIVE_NOT_RECRUITING | PHASE3
811 Participants

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-25
Completion: 2027-08-04
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05304585 | RECRUITING | PHASE3
205 Participants

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-04
Completion: 2030-06-30
Conditions
Embryonal Rhabdomyosarcoma Fusion-Negative Alveolar Rhabdomyosarcoma Spindle Cell/Sclerosing Rhabdomyosarcoma
Interventions
PROCEDURE DRUG BIOLOGICAL RADIATION
No Results Yet
NCT05288543 | TERMINATED | PHASE1
63 Participants

A Study of Orally Administered IPG7236 in Healthy Adult Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-07
Completion: 2023-03-31
Conditions
Atopic Dermatitis
Interventions
DRUG OTHER
No Results Yet
NCT05284513 | ENROLLING_BY_INVITATION | NA
532 Participants

Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-09
Completion: 2027-01-31
Conditions
Familial Hypercholesterolemia
Interventions
BEHAVIORAL
No Results Yet
NCT05271409 | RECRUITING | PHASE3
152 Participants

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-30
Completion: 2025-11-20
Conditions
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
Interventions
DRUG OTHER
No Results Yet
NCT05268289 | RECRUITING | PHASE2
240 Participants

Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-10
Completion: 2026-03-30
Conditions
Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05258435 | ACTIVE_NOT_RECRUITING
131 Participants

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-09
Completion: 2028-04-30
Conditions
Cervical Disc Disease Degenerative Disc Disease
Interventions
DEVICE
No Results Yet
NCT05241860 | ACTIVE_NOT_RECRUITING | PHASE2
79 Participants

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-21
Completion: 2025-09-29
Conditions
Castration-Sensitive Prostate Carcinoma Metastatic Prostate Carcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8
Interventions
OTHER
No Results Yet
NCT05235165 | RECRUITING | PHASE3
250 Participants

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-01
Completion: 2031-03-31
Conditions
Metastatic Malignant Neoplasm in the Lung Metastatic Osteosarcoma Osteosarcoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05228275 | ACTIVE_NOT_RECRUITING
549 Participants

Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-08
Completion: 2027-09-30
Conditions
COVID-19 Infection Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm
Interventions
PROCEDURE OTHER
No Results Yet
NCT05218655 | COMPLETED | PHASE3
101 Participants

A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-22
Completion: 2025-04-15
Conditions
Inherited Mitochondrial Disease
Interventions
DRUG
NCT05202093 | COMPLETED | NA
129 Participants

Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-05
Completion: 2022-07-15
Conditions
Tooth Bleaching
Interventions
DEVICE
NCT05199688 | RECRUITING | PHASE3
8 Participants

A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-12-31
Completion: 2027-03-31
Conditions
Neuromyelitis Optica Spectrum Disorder NMOSD
Interventions
DRUG
No Results Yet
NCT05193396 | RECRUITING | PHASE4
100 Participants

Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-01
Completion: 2026-01-31
Conditions
Adrenal Insufficiency Polymyalgia Rheumatica (PMR) Giant Cell Arteritis (GCA)
Interventions
DRUG
No Results Yet
NCT05187429 | RECRUITING | PHASE1/PHASE2
42 Participants

Low Dose Nivolumab in Adults Living With HIV on Antiretroviral Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-01-24
Completion: 2029-01-31
Conditions
HIV I Infection
Interventions
DRUG
No Results Yet
NCT05174780 | COMPLETED | NA
159 Participants

Myopia Control With a Innovative Spectacle Lens

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-29
Completion: 2025-10-20
Conditions
Myopia
Interventions
DEVICE
No Results Yet
NCT05173844 | COMPLETED | NA
128 Participants

Digital Sleep Therapy for Older Adults With Cognitive Impairment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-10
Completion: 2025-07-01
Conditions
Insomnia Type; Sleep Disorder Cognitive Impairment
Interventions
OTHER
No Results Yet
NCT05172973 | RECRUITING | NA
200 Participants

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-11-22
Completion: 2026-12-31
Conditions
Aortic Valve Insufficiency Aortic Valve Stenosis
Interventions
DEVICE
No Results Yet
NCT05171686 | COMPLETED | PHASE4
49 Participants

Diuretics and Volume Overload in Early CKD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-02-01
Completion: 2025-10-02
Conditions
Chronic Kidney Disease Hypertension
Interventions
DRUG
No Results Yet
NCT05167045 | COMPLETED
20 Participants

A Pilot Study for the Brain Health Support Program

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-15
Completion: 2022-04-29
Conditions
Dementia Mild Cognitive Impairment Subjective Cognitive Impairment Pre-dementia Dementia Prevention
Interventions
BEHAVIORAL
No Results Yet
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