Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

NCT ID: NCT05241860

Last Updated: 2025-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

79 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-21

Study Completion Date

2033-09-01

Brief Summary

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This phase II trial examines antiandrogen therapy interruptions in patients with hormone-sensitive prostate cancer that has spread to other places in the body (metastatic) responding exceptionally well to androgen receptor-pathway inhibitor therapy. The usual treatment for patients with metastatic prostate cancer is to receive hormonal medications including a medication to decrease testosterone levels in the body and a potent oral hormonal medication to block growth signals from male hormones (like testosterone) in the cancer cells. Patients whose cancer is responding exceptionally well to this therapy may take a break from these medications according to their doctor's guidance. This trial may help doctors determine if stopping treatment can allow for testosterone recovery.

Detailed Description

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PRIMARY OBJECTIVE:

I. To determine the proportion of men who experience 18-month treatment-free interval from therapy with eugonadal testosterone (to \>= 150 ng/ml) after treatment interruption.

SECONDARY OBJECTIVES:

I. To determine time to eugonadal testosterone (\> 150 ng/dl). II. To determine duration off-treatment.

III. To assess changes in quality of life as follows:

1. To assess changes in patient-reported quality of life as assessed by the Functional Assessment of Cancer Therapy- Prostate (FACT-P) total score from baseline to 24 months after treatment interruption.
2. To assess changes in the FACT-P subscales (i.e., physical well-being, social and family well-being, emotional well-being, functional well-being, and prostate cancer subscale) from baseline to 24 months after treatment interruption.
3. To assess changes in the FACT-P total score and subscales (i.e., physical well-being, social and family well-being, emotional well-being, functional well-being, and prostate cancer subscale) from baseline to the remaining post-baseline time points (i.e., 6, 12, and 18 months) after treatment interruption.

OUTLINE:

Patients stop both hormonal medications (medication to decrease testosterone levels in the body and potent oral hormonal medication to block growth signals from male hormones in the cancer cells). Patients are then followed every 12 months for symptoms. Patients with an increase in prostate specific antigen (PSA) level to greater than or equal to 5 ng/ml, changes on imaging studies suggesting that their cancer is growing back, or symptoms that the doctor thinks is related to their cancer growing back, resume both hormonal treatments.

After completion of study treatment, patients are followed up every 6 months for 10 years from registration or withdrawal from the study or death.

Conditions

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Castration-Sensitive Prostate Carcinoma Metastatic Prostate Carcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment (discontinue hormonal medication, follow up)

Patients stop both hormonal medications (medication to decrease testosterone levels in the body and potent oral hormonal medication to block growth signals from male hormones in the cancer cells). Patients are then followed every 12 months for symptoms. Patients with an increase in PSA level to greater than or equal to 5 ng/ml, changes on imaging studies suggesting that their cancer is growing back, or symptoms that the doctor thinks is related to their cancer growing back, resume both hormonal treatments.

Group Type EXPERIMENTAL

Pharmacotherapy Discontinuation

Intervention Type OTHER

Stop hormonal medications (Abiraterone, Enzalutamide, Apalutamide, Leuprolide, Goserelin, Degarelix, Relugolix)

Follow-Up

Intervention Type OTHER

Undergo follow-up

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Interventions

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Pharmacotherapy Discontinuation

Stop hormonal medications (Abiraterone, Enzalutamide, Apalutamide, Leuprolide, Goserelin, Degarelix, Relugolix)

Intervention Type OTHER

Follow-Up

Undergo follow-up

Intervention Type OTHER

Questionnaire Administration

Ancillary studies

Intervention Type OTHER

Quality-of-Life Assessment

Ancillary studies

Intervention Type OTHER

Other Intervention Names

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Medication Discontinuation

Eligibility Criteria

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Inclusion Criteria

* Histologic or clinical diagnosis of metastatic prostate cancer
* Must have had evidence of metastatic disease by bone scan, or nodal or visceral lesions on computed tomography (CT) or magnetic resonance imaging (MRI) prior to starting on intense antiandrogen therapy (ADT)

* Radiographic evidence of disease is not required at the time of enrollment
* No metastases to liver or to brain, as these represent aggressive variant disease biology for which intermittent treatment may not be favored
* Must currently be receiving intense ADT for metastatic hormone sensitive prostate cancer (mHSPC)

* Testosterone suppression (TS) with luteinizing hormone releasing hormone (LHRH)-agonist or LHRH-antagonist AND
* An approved secondary androgen receptor pathway inhibitor (ARPI) abiraterone, enzalutamide, or apalutamide (or darolutamide if approved for this indication)
* Must have remained on testosterone suppression for metastatic disease continuously (without treatment breaks) for 540-750 days (approximately 18 to 24 months) from time of first dose of LHRH agonist or antagonist by time of registration. A period of anti-androgen treatment prior to LHRH agonist or antagonist initiation is not included in the 540 - 750 days (approximately 18 to 24 months)
* Must have received treatment with ARPI for at least 360 days in total by time of A032101 registration. Treatment breaks from ARPI of up to 28 days are permitted (for example peri-procedural or for management of a temporary adverse event) as long as PSA did not rise while holding therapy
* Prior TS in the context of neoadjuvant/concurrent/adjuvant treatment with local therapy is permitted. Prior course(s) of intermittent TS for biochemical-only recurrence is permitted. However, if the patient previously received TS, metastatic progression for which intense ADT was initiated must have occurred during an off-treatment interval and with testosterone \>= 150 ng/dL
* Prior local therapy for prostate cancer (either before or after diagnosis of metastatic disease) is permitted. Prior treatment with docetaxel chemotherapy for up to 6 cycles is permitted. Prior radiation therapy to metastatic sites (either for symptom palliation or for ablation of oligometastatic disease) is permitted

Exclusion Criteria

* No history of surgical castration
* No history of ARPI use prior to diagnosis of mHSPC for which the patient is currently receiving intense ADT (such as in the neoadjuvant setting with prior local therapy)
* No current or prior treatment with experimental agents for metastatic hormone-sensitive prostate cancer
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* Prior to initiating intense ADT

* Prostate specific antigen (PSA) \>= 5 ng/ml
* Testosterone \>= 150 ng/dl. Patients are permitted to enroll if testosterone was not measured prior to initiating intense ADT for mHSPC if they did not previously receive TS and were not known or suspected to be hypogonadal at the time
* At time of enrollment to A032101

* PSA \< 0.2 ng/ml

\*\* PSA values (measured in the same laboratory) must be stable or falling for 3 consecutive measurements - i.e. any PSA rise must be followed by a decrease in PSA that is further decreased or stable on a 3rd measurement. Any patient with 2 consecutive rises in PSA values since achieving castrate level of testosterone is not eligible
* Testosterone \< 50 ng/dl
* No current participation in a clinical study that does not allow for TS or ARPI interruption
* No patients with a "currently active" second malignancy \* Patients with non-melanomatous skin cancer, superficial bladder cancer, cancer not needing active therapy for at least 2 years, cancer for which the treating investigator deems the subject
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Alliance for Clinical Trials in Oncology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Atish D. Choudhury, MD, PhD

Role: STUDY_CHAIR

Dana-Farber Cancer Institute

Locations

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Cancer Center at Saint Joseph's

Phoenix, Arizona, United States

Site Status

Mercy Hospital Fort Smith

Fort Smith, Arkansas, United States

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CARTI Cancer Center

Little Rock, Arkansas, United States

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Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, United States

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Mercy Cancer Center �� Carmichael

Carmichael, California, United States

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Mercy San Juan Medical Center

Carmichael, California, United States

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Epic Care-Dublin

Dublin, California, United States

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Mercy Cancer Center - Elk Grove

Elk Grove, California, United States

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Bay Area Breast Surgeons Inc

Emeryville, California, United States

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Epic Care Partners in Cancer Care

Emeryville, California, United States

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Contra Costa Regional Medical Center

Martinez, California, United States

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Mercy UC Davis Cancer Center

Merced, California, United States

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Bay Area Tumor Institute

Oakland, California, United States

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UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, United States

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Eisenhower Medical Center

Rancho Mirage, California, United States

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Mercy Cancer Center - Rocklin

Rocklin, California, United States

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Mercy Cancer Center - Sacramento

Sacramento, California, United States

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Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, United States

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Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, United States

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Epic Care Cyberknife Center

Walnut Creek, California, United States

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Woodland Memorial Hospital

Woodland, California, United States

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Rocky Mountain Regional VA Medical Center

Aurora, Colorado, United States

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Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, United States

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Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, United States

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Saint Francis Cancer Center

Colorado Springs, Colorado, United States

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Porter Adventist Hospital

Denver, Colorado, United States

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Mercy Medical Center

Durango, Colorado, United States

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Southwest Oncology PC

Durango, Colorado, United States

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Saint Anthony Hospital

Lakewood, Colorado, United States

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Littleton Adventist Hospital

Littleton, Colorado, United States

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Longmont United Hospital

Longmont, Colorado, United States

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Parker Adventist Hospital

Parker, Colorado, United States

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Saint Mary Corwin Medical Center

Pueblo, Colorado, United States

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UM Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, United States

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UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, United States

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UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, United States

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University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, United States

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UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, United States

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UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, United States

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Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States

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Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, United States

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Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, United States

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Walter Knox Memorial Hospital

Emmett, Idaho, United States

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Idaho Urologic Institute-Meridian

Meridian, Idaho, United States

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Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, United States

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Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, United States

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Kootenai Cancer Clinic

Sandpoint, Idaho, United States

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Saint Anthony's Health

Alton, Illinois, United States

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Illinois CancerCare-Bloomington

Bloomington, Illinois, United States

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Illinois CancerCare-Canton

Canton, Illinois, United States

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Memorial Hospital of Carbondale

Carbondale, Illinois, United States

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SIH Cancer Institute

Carterville, Illinois, United States

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Illinois CancerCare-Carthage

Carthage, Illinois, United States

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Centralia Oncology Clinic

Centralia, Illinois, United States

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Saint Mary's Hospital

Centralia, Illinois, United States

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Northwestern University

Chicago, Illinois, United States

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University of Chicago Comprehensive Cancer Center

Chicago, Illinois, United States

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Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, United States

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Decatur Memorial Hospital

Decatur, Illinois, United States

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Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, United States

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Illinois CancerCare-Dixon

Dixon, Illinois, United States

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Crossroads Cancer Center

Effingham, Illinois, United States

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Illinois CancerCare-Eureka

Eureka, Illinois, United States

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Illinois CancerCare-Galesburg

Galesburg, Illinois, United States

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Western Illinois Cancer Treatment Center

Galesburg, Illinois, United States

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Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, United States

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Ingalls Memorial Hospital

Harvey, Illinois, United States

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Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, United States

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Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, United States

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Illinois CancerCare-Macomb

Macomb, Illinois, United States

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Good Samaritan Regional Health Center

Mount Vernon, Illinois, United States

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UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, United States

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Cancer Care Center of O'Fallon

O'Fallon, Illinois, United States

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HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, United States

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Northwestern Medicine Orland Park

Orland Park, Illinois, United States

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University of Chicago Medicine-Orland Park

Orland Park, Illinois, United States

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Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, United States

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Illinois CancerCare-Pekin

Pekin, Illinois, United States

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OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

Pekin, Illinois, United States

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Illinois CancerCare-Peoria

Peoria, Illinois, United States

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OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, United States

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Methodist Medical Center of Illinois

Peoria, Illinois, United States

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OSF Saint Francis Medical Center

Peoria, Illinois, United States

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Illinois CancerCare-Peru

Peru, Illinois, United States

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Valley Radiation Oncology

Peru, Illinois, United States

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Illinois CancerCare-Princeton

Princeton, Illinois, United States

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Memorial Hospital East

Shiloh, Illinois, United States

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Southern Illinois University School of Medicine

Springfield, Illinois, United States

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Springfield Clinic

Springfield, Illinois, United States

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Memorial Medical Center

Springfield, Illinois, United States

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Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States

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Illinois CancerCare - Washington

Washington, Illinois, United States

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Reid Health

Richmond, Indiana, United States

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Mary Greeley Medical Center

Ames, Iowa, United States

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McFarland Clinic - Ames

Ames, Iowa, United States

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McFarland Clinic - Boone

Boone, Iowa, United States

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Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, United States

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Mercy Cancer Center-West Lakes

Clive, Iowa, United States

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Alegent Health Mercy Hospital

Council Bluffs, Iowa, United States

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Greater Regional Medical Center

Creston, Iowa, United States

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Mercy Medical Center - Des Moines

Des Moines, Iowa, United States

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Mission Cancer and Blood - Laurel

Des Moines, Iowa, United States

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McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, United States

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McFarland Clinic - Jefferson

Jefferson, Iowa, United States

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McFarland Clinic - Marshalltown

Marshalltown, Iowa, United States

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Mercy Medical Center-West Lakes

West Des Moines, Iowa, United States

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Central Care Cancer Center - Garden City

Garden City, Kansas, United States

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Central Care Cancer Center - Great Bend

Great Bend, Kansas, United States

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Flaget Memorial Hospital

Bardstown, Kentucky, United States

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Commonwealth Cancer Center-Corbin

Corbin, Kentucky, United States

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Saint Joseph Hospital

Lexington, Kentucky, United States

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Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, United States

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Saint Joseph Hospital East

Lexington, Kentucky, United States

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Saint Joseph London

London, Kentucky, United States

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Saint Joseph Mount Sterling

Mount Sterling, Kentucky, United States

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Dana-Farber Cancer Institute

Boston, Massachusetts, United States

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Dana-Farber Cancer Institute at Foxborough

Foxborough, Massachusetts, United States

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Dana-Farber/Brigham and Women's Cancer Center at Milford Regional

Milford, Massachusetts, United States

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Dana-Farber/Brigham and Women's Cancer Center at South Shore

South Weymouth, Massachusetts, United States

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UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, United States

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Hickman Cancer Center

Adrian, Michigan, United States

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Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States

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University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

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Saint Joseph Mercy Brighton

Brighton, Michigan, United States

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Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, United States

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University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, United States

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Saint Joseph Mercy Canton

Canton, Michigan, United States

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Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, United States

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Caro Cancer Center

Caro, Michigan, United States

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Saint Joseph Mercy Chelsea

Chelsea, Michigan, United States

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Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, United States

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Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, United States

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Newland Medical Associates-Clarkston

Clarkston, Michigan, United States

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Ascension Saint John Hospital

Detroit, Michigan, United States

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Great Lakes Cancer Management Specialists-Doctors Park

East China Township, Michigan, United States

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Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, United States

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Genesee Hematology Oncology PC

Flint, Michigan, United States

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Genesys Hurley Cancer Institute

Flint, Michigan, United States

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Hurley Medical Center

Flint, Michigan, United States

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Academic Hematology Oncology Specialists

Grosse Pointe Woods, Michigan, United States

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Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

Grosse Pointe Woods, Michigan, United States

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Michigan Breast Specialists-Grosse Pointe Woods

Grosse Pointe Woods, Michigan, United States

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University of Michigan Health - Sparrow Lansing

Lansing, Michigan, United States

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Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, United States

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Great Lakes Cancer Management Specialists-Macomb Medical Campus

Macomb, Michigan, United States

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Michigan Breast Specialists-Macomb Township

Macomb, Michigan, United States

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Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, United States

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Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, United States

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21st Century Oncology-Pontiac

Pontiac, Michigan, United States

Site Status

Hope Cancer Center

Pontiac, Michigan, United States

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Newland Medical Associates-Pontiac

Pontiac, Michigan, United States

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Saint Joseph Mercy Oakland

Pontiac, Michigan, United States

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Ascension Saint Mary's Hospital

Saginaw, Michigan, United States

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Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, United States

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Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, United States

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Ascension Saint Joseph Hospital

Tawas City, Michigan, United States

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Advanced Breast Care Center PLLC

Warren, Michigan, United States

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Great Lakes Cancer Management Specialists-Macomb Professional Building

Warren, Michigan, United States

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Macomb Hematology Oncology PC

Warren, Michigan, United States

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Michigan Breast Specialists-Warren

Warren, Michigan, United States

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Saint John Macomb-Oakland Hospital

Warren, Michigan, United States

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Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, United States

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Huron Gastroenterology PC

Ypsilanti, Michigan, United States

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Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, United States

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Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, United States

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Fairview Ridges Hospital

Burnsville, Minnesota, United States

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Minnesota Oncology - Burnsville

Burnsville, Minnesota, United States

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Cambridge Medical Center

Cambridge, Minnesota, United States

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Mercy Hospital

Coon Rapids, Minnesota, United States

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Fairview Southdale Hospital

Edina, Minnesota, United States

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Unity Hospital

Fridley, Minnesota, United States

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Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, United States

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Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, United States

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Saint John's Hospital - Healtheast

Maplewood, Minnesota, United States

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Abbott-Northwestern Hospital

Minneapolis, Minnesota, United States

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Hennepin County Medical Center

Minneapolis, Minnesota, United States

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Health Partners Inc

Minneapolis, Minnesota, United States

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Monticello Cancer Center

Monticello, Minnesota, United States

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New Ulm Medical Center

New Ulm, Minnesota, United States

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Fairview Northland Medical Center

Princeton, Minnesota, United States

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North Memorial Medical Health Center

Robbinsdale, Minnesota, United States

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Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, United States

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Regions Hospital

Saint Paul, Minnesota, United States

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United Hospital

Saint Paul, Minnesota, United States

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Saint Francis Regional Medical Center

Shakopee, Minnesota, United States

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Lakeview Hospital

Stillwater, Minnesota, United States

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Sanford Thief River Falls Medical Center

Thief River Falls, Minnesota, United States

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Ridgeview Medical Center

Waconia, Minnesota, United States

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Rice Memorial Hospital

Willmar, Minnesota, United States

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Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, United States

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Sanford Cancer Center Worthington

Worthington, Minnesota, United States

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Fairview Lakes Medical Center

Wyoming, Minnesota, United States

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Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, United States

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Central Care Cancer Center - Bolivar

Bolivar, Missouri, United States

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Cox Cancer Center Branson

Branson, Missouri, United States

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Saint Francis Medical Center

Cape Girardeau, Missouri, United States

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Southeast Cancer Center

Cape Girardeau, Missouri, United States

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Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, United States

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Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States

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Parkland Health Center - Farmington

Farmington, Missouri, United States

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Capital Region Southwest Campus

Jefferson City, Missouri, United States

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Freeman Health System

Joplin, Missouri, United States

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Mercy Hospital Joplin

Joplin, Missouri, United States

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Lake Regional Hospital

Osage Beach, Missouri, United States

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Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, United States

Site Status

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, United States

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Heartland Regional Medical Center

Saint Joseph, Missouri, United States

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Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, United States

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Mercy Hospital Springfield

Springfield, Missouri, United States

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CoxHealth South Hospital

Springfield, Missouri, United States

Site Status

Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

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Mercy Hospital South

St Louis, Missouri, United States

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Siteman Cancer Center-South County

St Louis, Missouri, United States

Site Status

Missouri Baptist Medical Center

St Louis, Missouri, United States

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Siteman Cancer Center at Christian Hospital

St Louis, Missouri, United States

Site Status

Mercy Hospital Saint Louis

St Louis, Missouri, United States

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Missouri Baptist Sullivan Hospital

Sullivan, Missouri, United States

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BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, United States

Site Status

Mercy Hospital Washington

Washington, Missouri, United States

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Community Hospital of Anaconda

Anaconda, Montana, United States

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Billings Clinic Cancer Center

Billings, Montana, United States

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Bozeman Deaconess Hospital

Bozeman, Montana, United States

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Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, United States

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Great Falls Clinic

Great Falls, Montana, United States

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Kalispell Regional Medical Center

Kalispell, Montana, United States

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Community Medical Hospital

Missoula, Montana, United States

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CHI Health Saint Francis

Grand Island, Nebraska, United States

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CHI Health Good Samaritan

Kearney, Nebraska, United States

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Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, United States

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Alegent Health Immanuel Medical Center

Omaha, Nebraska, United States

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Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, United States

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Alegent Health Lakeside Hospital

Omaha, Nebraska, United States

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Creighton University Medical Center

Omaha, Nebraska, United States

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Midlands Community Hospital

Papillion, Nebraska, United States

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Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, United States

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Monmouth Medical Center Southern Campus

Lakewood, New Jersey, United States

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Saint Barnabas Medical Center

Livingston, New Jersey, United States

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Monmouth Medical Center

Long Branch, New Jersey, United States

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Memorial Sloan Kettering Monmouth

Middletown, New Jersey, United States

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Memorial Sloan Kettering Bergen

Montvale, New Jersey, United States

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Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

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Community Medical Center

Toms River, New Jersey, United States

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Memorial Sloan Kettering Commack

Commack, New York, United States

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Memorial Sloan Kettering Westchester

Harrison, New York, United States

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Garnet Health Medical Center

Middletown, New York, United States

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Memorial Sloan Kettering Cancer Center

New York, New York, United States

Site Status

Upstate Cancer Center at Oswego

Oswego, New York, United States

Site Status

State University of New York Upstate Medical University

Syracuse, New York, United States

Site Status

SUNY Upstate Medical Center-Community Campus

Syracuse, New York, United States

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Montefiore Medical Center-Einstein Campus

The Bronx, New York, United States

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Montefiore Medical Center-Weiler Hospital

The Bronx, New York, United States

Site Status

Montefiore Medical Center - Moses Campus

The Bronx, New York, United States

Site Status

Memorial Sloan Kettering Nassau

Uniondale, New York, United States

Site Status

Upstate Cancer Center at Verona

Verona, New York, United States

Site Status

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, United States

Site Status

Sanford Bismarck Medical Center

Bismarck, North Dakota, United States

Site Status

Sanford South University Medical Center

Fargo, North Dakota, United States

Site Status

Southpointe-Sanford Medical Center Fargo

Fargo, North Dakota, United States

Site Status

Sanford Medical Center Fargo

Fargo, North Dakota, United States

Site Status

Sanford Broadway Medical Center

Fargo, North Dakota, United States

Site Status

Sanford Roger Maris Cancer Center

Fargo, North Dakota, United States

Site Status

Indu and Raj Soin Medical Center

Beavercreek, Ohio, United States

Site Status

Saint Elizabeth Boardman Hospital

Boardman, Ohio, United States

Site Status

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, United States

Site Status

Miami Valley Hospital South

Centerville, Ohio, United States

Site Status

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, United States

Site Status

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, United States

Site Status

Bethesda North Hospital

Cincinnati, Ohio, United States

Site Status

TriHealth Cancer Institute-Westside

Cincinnati, Ohio, United States

Site Status

TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, United States

Site Status

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status

Dayton Blood and Cancer Center

Dayton, Ohio, United States

Site Status

Miami Valley Hospital

Dayton, Ohio, United States

Site Status

Dayton Physician LLC-Miami Valley Hospital North

Dayton, Ohio, United States

Site Status

Miami Valley Hospital North

Dayton, Ohio, United States

Site Status

Armes Family Cancer Center

Findlay, Ohio, United States

Site Status

Blanchard Valley Hospital

Findlay, Ohio, United States

Site Status

Orion Cancer Care

Findlay, Ohio, United States

Site Status

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, United States

Site Status

Dayton Physicians LLC-Atrium

Franklin, Ohio, United States

Site Status

Dayton Physicians LLC-Wayne

Greenville, Ohio, United States

Site Status

Miami Valley Cancer Care and Infusion

Greenville, Ohio, United States

Site Status

Wayne Hospital

Greenville, Ohio, United States

Site Status

Greater Dayton Cancer Center

Kettering, Ohio, United States

Site Status

Kettering Medical Center

Kettering, Ohio, United States

Site Status

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, United States

Site Status

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, United States

Site Status

Dayton Physicians LLC - Troy

Troy, Ohio, United States

Site Status

Upper Valley Medical Center

Troy, Ohio, United States

Site Status

Saint Joseph Warren Hospital

Warren, Ohio, United States

Site Status

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, United States

Site Status

Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, United States

Site Status

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, United States

Site Status

Saint Alphonsus Medical Center-Baker City

Baker City, Oregon, United States

Site Status

Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, United States

Site Status

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, United States

Site Status

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, United States

Site Status

Pocono Medical Center

East Stroudsburg, Pennsylvania, United States

Site Status

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, United States

Site Status

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status

Jefferson Methodist Hospital

Philadelphia, Pennsylvania, United States

Site Status

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, United States

Site Status

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States

Site Status

Saint Joseph Regional Cancer Center

Bryan, Texas, United States

Site Status

Sovah Health Martinsville

Martinsville, Virginia, United States

Site Status

Harrison Medical Center

Bremerton, Washington, United States

Site Status

Highline Medical Center-Main Campus

Burien, Washington, United States

Site Status

Saint Elizabeth Hospital

Enumclaw, Washington, United States

Site Status

Saint Francis Hospital

Federal Way, Washington, United States

Site Status

Saint Clare Hospital

Lakewood, Washington, United States

Site Status

Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, United States

Site Status

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, United States

Site Status

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, United States

Site Status

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, United States

Site Status

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, United States

Site Status

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, United States

Site Status

Drexel Town Square Health Center

Oak Creek, Wisconsin, United States

Site Status

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, United States

Site Status

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, United States

Site Status

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, United States

Site Status

Marshfield Medical Center - Weston

Weston, Wisconsin, United States

Site Status

Billings Clinic-Cody

Cody, Wyoming, United States

Site Status

Welch Cancer Center

Sheridan, Wyoming, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

U10CA180821

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCI-2021-13974

Identifier Type: REGISTRY

Identifier Source: secondary_id

A032101

Identifier Type: -

Identifier Source: org_study_id