Safety and Effectiveness of Restylane® Kysse for Lip Augmentation in Chinese Subjects

NCT ID: NCT05342753

Last Updated: 2025-12-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-13

Study Completion Date

2024-11-07

Brief Summary

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Open-label, phase IV, post-marketing study to evaluate aesthetic improvement in Chinese subjects after treatment with Restylane Kysse.

Detailed Description

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Conditions

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Lip Augmentation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Restylane Kysse

Hyaluronic Acid

Group Type EXPERIMENTAL

Restylane Kysse

Intervention Type DEVICE

Hyaluronic Acid: Injectable gel for lip augmentation and the correction of upper perioral rhytids

Interventions

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Restylane Kysse

Hyaluronic Acid: Injectable gel for lip augmentation and the correction of upper perioral rhytids

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Participants willing to comply with the requirements of the study and providing a signed written informed consent
* Ability to adequately understand the verbal explanations and the written subject information provided in English
* Subjects seeking augmentation therapy for the lips
* Adult males or non-pregnant, non-breastfeeding females, 22 years of age or older with both biological parents of full Chinese descent

Exclusion Criteria

* Known/previous allergy or hypersensitivity to any injectable hyaluronic acid (HA) gel or to gram-positive bacterial proteins
* Previous use of any permanent (non-biodegradable) or semipermanent (e.g., calcium hydroxylapatite or poly-L-lactic acid) facial tissue augmentation therapy, lifting threads, permanent implants or autologous fat below the level of the lower orbital rim.
* Previous use of any HA-based or collagen-based biodegradable facial tissue augmentation therapy below the level of the lower orbital rim within 12 months prior to the baseline visit.
* Previous facial surgery, within 6 months, below the level of the lower orbital rim
* Previous surgery to the upper or lower lip, lip piercing or tattoo, or history of facial trauma.
* Participation in any interventional clinical study within 30 days of screening
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Galderma R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Study Director

Role: STUDY_DIRECTOR

Galderma R&D

Locations

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Galderma Research Site

Los Angeles, California, United States

Site Status

Galderma Research Site

Vista, California, United States

Site Status

Galderma Research Site

Ardmore, Pennsylvania, United States

Site Status

Countries

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Taiwan United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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05DF2007

Identifier Type: -

Identifier Source: org_study_id