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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05171075 | ACTIVE_NOT_RECRUITING | PHASE3
417 Participants

A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-27
Completion: 2026-12-31
Conditions
Venous Thromboembolism Deep Venous Thrombosis Pulmonary Embolism
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05153395 | SUSPENDED | EARLY_PHASE1
65 Participants

Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-12-01
Completion: 2027-06-30
Conditions
Healthy Vasodilation Insulin Resistance Autonomic Dysfunction Obesity
Interventions
OTHER DRUG
No Results Yet
NCT05138848 | RECRUITING | EARLY_PHASE1
116 Participants

Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-01-03
Completion: 2026-05-31
Conditions
Alzheimer Disease, Late Onset Mild Cognitive Impairment Sleep Cognitive Change Amyloid
Interventions
BEHAVIORAL
No Results Yet
NCT05115630 | COMPLETED | PHASE2
24 Participants

Off-the-shelf NK Cells + SCT for Myeloid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-04-08
Completion: 2025-05-15
Conditions
Myeloid Malignancies Acute Myeloid Leukemia Myelodysplastic Syndrome Chronic Myeloid Leukemia
Interventions
DRUG
Results Available
NCT05093933 | COMPLETED | PHASE3
6106 Participants

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-11-02
Completion: 2024-11-20
Conditions
Chronic Heart Failure With Reduced Ejection Fraction
Interventions
DRUG
Results Available
NCT05088798 | RECRUITING | PHASE2
100 Participants

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-09-10
Completion: 2030-01-01
Conditions
Hyperinsulinism
Interventions
DRUG
No Results Yet
NCT05088356 | RECRUITING | PHASE1
60 Participants

Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-09-07
Completion: 2027-11-30
Conditions
Allogeneic Hematopoietic Cell Transplantation (HCT) Advanced Hematologic Malignancies Acute Leukemia Chronic Myelogenous Leukemia Myelodysplastic Syndromes Myeloproliferative Disorders
Interventions
DRUG DEVICE
No Results Yet
NCT05083182 | ACTIVE_NOT_RECRUITING | PHASE3
48 Participants

A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-30
Completion: 2026-12-10
Conditions
Arthritis, Juvenile
Interventions
DRUG
No Results Yet
NCT05071352 | COMPLETED | PHASE3
60 Participants

Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-10-01
Completion: 2023-03-01
Conditions
Analgesia Critical Illness Mechanical Ventilation Sedation
Interventions
DRUG
No Results Yet
NCT05069259 | TERMINATED
18 Participants

Generate Real World Data On Tofacitinib Induction Therapy and Changes In Clinical and Patient Reported Outcomes.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-03-28
Completion: 2024-04-30
Conditions
Ulcerative Colitis
Interventions
OTHER
Results Available
NCT05063162 | RECRUITING | PHASE3
104 Participants

A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOG-AD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-02-02
Completion: 2027-05-06
Conditions
Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOG-AD)
Interventions
DRUG OTHER
No Results Yet
NCT05061238 | ACTIVE_NOT_RECRUITING | NA
15 Participants

Impact Of Muscle Vibration On Gait Control

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-10-04
Completion: 2027-12-31
Conditions
Muscle
Interventions
DEVICE
No Results Yet
NCT05047536 | TERMINATED | PHASE1
61 Participants

KZR-261 in Subjects With Advanced Solid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-09-30
Completion: 2025-01-17
Conditions
Advanced/Metastatic Solid Tumor
Interventions
DRUG
Results Available
NCT05039281 | RECRUITING | PHASE1/PHASE2
6 Participants

Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-23
Completion: 2027-12-31
Conditions
Recurrent Glioblastoma Recurrent Gliosarcoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05036616 | COMPLETED | NA
80 Participants

Separation Versus Integrated Approach in Combining ECMO With CRRT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-04-01
Completion: 2025-03-10
Conditions
AKI
Interventions
DEVICE
No Results Yet
NCT04996082 | COMPLETED
26 Participants

Skin Fibrosis Analysis by Raman Spectroscopy in Systemic Sclerosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-04-08
Completion: 2023-07-21
Conditions
Validation of Raman Spectroscopy Usefulness in Systemic Sclerosis
No Results Yet
NCT04983654 | COMPLETED | NA
70 Participants

Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-02-09
Completion: 2023-10-03
Conditions
Ulcer Anemia Sickle Cell Disease
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04968288 | RECRUITING
195 Participants

Natural History of KSHV-Associated Multicentric Castleman s Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-11-17
Completion: 2034-01-01
Conditions
Multicentric Castleman s Disease
No Results Yet
NCT04962477 | COMPLETED
48 Participants

Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-03-02
Completion: 2023-09-27
Conditions
Pregnancy Related Innate Inflammatory Response
Interventions
OTHER
No Results Yet
NCT04960709 | ACTIVE_NOT_RECRUITING | PHASE3
712 Participants

Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-08-05
Completion: 2026-04-30
Conditions
Muscle Invasive Bladder Cancer
Interventions
DRUG PROCEDURE
No Results Yet
NCT04947865 | ACTIVE_NOT_RECRUITING | NA
60 Participants

Reflex Excitability in Post-stroke Stiff-Knee Gait

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-06-11
Completion: 2025-06-11
Conditions
Stroke Chronic Stroke Gait, Hemiplegic Gait, Spastic Gait Disorder, Sensorimotor Gait Disorders, Neurologic Walking, Difficulty
Interventions
OTHER DEVICE
No Results Yet
NCT04913038 | COMPLETED
50 Participants

Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-06-29
Completion: 2023-11-22
Conditions
Pain Pediatric ALL
No Results Yet
NCT04902703 | RECRUITING | PHASE2
42 Participants

Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-01
Completion: 2026-11-30
Conditions
Alzheimer Disease
Interventions
DRUG
No Results Yet
NCT04901195 | ACTIVE_NOT_RECRUITING | PHASE3
658 Participants

A Study to Test the Long-term Treatment of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-05-27
Completion: 2026-07-28
Conditions
Hidradenitis Suppurativa
Interventions
DRUG
No Results Yet
NCT04883957 | ACTIVE_NOT_RECRUITING | PHASE1
64 Participants

Study of BGB-11417 in Adult Participants With Mature B-cell Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-07-05
Completion: 2026-04-30
Conditions
Mature B-cell Malignancies
Interventions
DRUG
No Results Yet
NCT04883905 | RECRUITING
150 Participants

ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-04-26
Completion: 2027-04-01
Conditions
Acute Hepatic Porphyria
No Results Yet
NCT04870203 | RECRUITING | PHASE3
178 Participants

Combination of Baricitinib and Anti-TNF in Rheumatoid Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-07-15
Completion: 2027-03-31
Conditions
Rheumatoid Arthritis
Interventions
DRUG
No Results Yet
NCT04852289 | ACTIVE_NOT_RECRUITING
78 Participants

A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-04-20
Completion: 2026-12-31
Conditions
COVID-19
No Results Yet
NCT04841746 | COMPLETED | NA
22 Participants

Efficacy of FES Cycling After a Severe Form of COVID-19

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-06-02
Completion: 2024-10-02
Conditions
Covid19 Ventilators, Mechanical Respiratory Distress Syndrome
Interventions
BEHAVIORAL
No Results Yet
NCT04831138 | TERMINATED | NA
6 Participants

Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Metastatic Renal Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-03-24
Completion: 2023-04-04
Conditions
Renal Cell Carcinoma
Interventions
OTHER
Results Available
NCT04817449 | COMPLETED
160 Participants

Spectroscopy in Ovarian Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-06-28
Completion: 2023-10-01
Conditions
Ovarian Cancer Ovarian Neoplasms Ovary Cyst Ovary Disease
No Results Yet
NCT04802161 | ACTIVE_NOT_RECRUITING | PHASE2
50 Participants

Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-24
Completion: 2024-11-21
Conditions
Acute Myeloid Leukemia Acute Myeloid Leukemia Post Cytotoxic Therapy Acute Myeloid Leukemia With Multilineage Dysplasia Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Myeloproliferative Neoplasm
Interventions
PROCEDURE DRUG
Results Available
NCT04783701 | RECRUITING
360 Participants

Coronary CT Angio Evaluating Graft Patency in ACS Patients Treated With DAPT or Single ASA After CABG (CoCAP)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-05-17
Completion: 2026-02-01
Conditions
Acute Coronary Syndrome Coronary Bypass Stenosis
No Results Yet
NCT04783506 | COMPLETED
225 Participants

Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-04-28
Completion: 2025-06-15
Conditions
Suicide and Depression
Interventions
OTHER
No Results Yet
NCT04783233 | WITHDRAWN
0 Participants

Chitogel CSK-4 Gel as Packing in Tympanoplasty Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-01-14
Completion: 2021-11-03
Conditions
Tympanoplasty Surgery
Interventions
BIOLOGICAL
No Results Yet
NCT04782180 | COMPLETED | PHASE4
90 Participants

PrEP at a Syringe Services Program

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-02-01
Completion: 2024-11-11
Conditions
Hiv Substance Use Disorders
Interventions
DRUG BEHAVIORAL
Results Available
NCT04777357 | RECRUITING | PHASE3
380 Participants

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-04-28
Completion: 2027-03-31
Conditions
Depression Bipolar I Disorder
Interventions
DRUG
No Results Yet
NCT04773457 | ACTIVE_NOT_RECRUITING
220 Participants

Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2023-04-01
Completion: 2026-12-01
Conditions
Surgical Site Infection
Interventions
OTHER
No Results Yet
NCT04768309 | COMPLETED | NA
20 Participants

Impact of Intestinal Microbiota on Uremic Toxins Productions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-06-04
Completion: 2021-07-13
Conditions
CKD Uremia
Interventions
OTHER
No Results Yet
NCT04741269 | COMPLETED
98 Participants

Asymmetric Lack of Knee Flexion as a Symptom of DLM in Children

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-09-01
Completion: 2020-11-01
Conditions
Highlights a New Clinical Sign Which Point Out a Meniscus Posterior Luxation Because of a MCA-type DLM
Interventions
DIAGNOSTIC_TEST
No Results Yet
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