Separation Versus Integrated Approach in Combining ECMO With CRRT
NCT ID: NCT05036616
Last Updated: 2025-12-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2021-04-01
2025-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Separation technique
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Integration technique
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Interventions
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Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Eligibility Criteria
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Inclusion Criteria
2. Refractory volume overload
3. Refractory hyperkalemia, defined as serum potassium (K⁺) \> 6.2 mEq/L or presence of electrocardiographic changes
4. Anuria or oliguria, defined as urine output \< 0.5 mL/kg/hr for 6-12 hours
5. Elevated BUN \>100 mg/dL or presence of uremic symptoms Increased intracranial pressure
Exclusion Criteria
2. Heparin contraindication
3. Chronic kidney disease with CRRT
4. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction
18 Years
90 Years
ALL
No
Sponsors
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Chulalongkorn University
OTHER
Responsible Party
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Nattachai Srisawat ,M.D.
Faculty of Medicine
Locations
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Sasipha tachaboon
Bangkok, Bangkok, Thailand
Countries
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References
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Thy M, Augustin P, Tran-Dinh A, Montravers P, de Tymowski C. Renal Replacement Therapy for Patients Requiring Extracorporeal Membrane Oxygenation: A Multicenter International Survey. Blood Purif. 2022;51(11):899-906. doi: 10.1159/000522398. Epub 2022 Apr 7.
de Tymowski C, Desmard M, Lortat-Jacob B, Pellenc Q, Alkhoder S, Alouache A, Fritz B, Montravers P, Augustin P. Impact of connecting continuous renal replacement therapy to the extracorporeal membrane oxygenation circuit. Anaesth Crit Care Pain Med. 2018 Dec;37(6):557-564. doi: 10.1016/j.accpm.2018.02.024. Epub 2018 Mar 20.
Other Identifiers
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IRB.151/64
Identifier Type: -
Identifier Source: org_study_id