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Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

NCT ID: NCT04773457

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

220 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-01

Study Completion Date

2026-12-01

Brief Summary

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Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.

Detailed Description

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Conditions

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Surgical Site Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Spine Surgery

Pediatric patients presenting for elective spine fusion surgery at Boston Children's Hospital

Surgical Site Infection

Intervention Type OTHER

infection at the site of the surgery (spine or abdomen)

Abdominal Surgery

Pediatric patients presenting for elective abdominal surgery at Boston Children's Hospital

Surgical Site Infection

Intervention Type OTHER

infection at the site of the surgery (spine or abdomen)

Interventions

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Surgical Site Infection

infection at the site of the surgery (spine or abdomen)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* scheduled for an elective open gastrointestinal surgical procedure or spine fusion surgery

Exclusion Criteria

* On chronic immunosuppressive drugs such as chronic corticosteroid use
* preexisting immunodeficiency diseases
Minimum Eligible Age

12 Months

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Koichi Yuki

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Koichi Yuki, MD

Role: PRINCIPAL_INVESTIGATOR

Boston Children's Hospital

Locations

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Boston Children's Hopsital

Boston, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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IRB-P00037804

Identifier Type: -

Identifier Source: org_study_id