TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery

NCT ID: NCT07237438

Last Updated: 2025-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-20

Study Completion Date

2026-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is aimed at clarifying changes in body composition during the perioperative period and identifying risk factors for skeletal muscle mass loss in patients with colorectal cancer. The investigators will asess the impact of the type of anaesthesia (total intravenous anaesthesia/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass, which will be evaluated using ultrasound, dynamometry and bioimpedance.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colorectal Cancer (CRC) Sarcopenia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

total intravenous anaesthesia

Group Type ACTIVE_COMPARATOR

total intravenous anaesthesia

Intervention Type PROCEDURE

evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass

sevoflurane anaesthesia

Group Type ACTIVE_COMPARATOR

sevoflurane anaesthesia

Intervention Type PROCEDURE

evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

total intravenous anaesthesia

evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass

Intervention Type PROCEDURE

sevoflurane anaesthesia

evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

• adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iaşi, Romania

Exclusion Criteria

* lack the capacity to consent
* extremity amputation
* paraplegia
* diseases affecting the muscles (such as stroke, lower-limb immobilization from a plaster, neurodegenerative diseases, peripheral neuropathy or muscle dystrophy)
* terminal cancer
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Regional Institute of Oncology, Iasi, Romania

UNKNOWN

Sponsor Role collaborator

Grigore T. Popa University of Medicine and Pharmacy

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Ianis Siriopol

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Regional Institute of Oncology, Iaşi, Romania

Iași, , Romania

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Romania

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Ianis Siriopol

Role: CONTACT

+40 746215 967

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Ianis Siriopol

Role: primary

+40 746 215 967

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

358/11.08.2025

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Anesthesia and Cancer Study: Renal Cell Carcinoma
NCT04503148 ACTIVE_NOT_RECRUITING NA
TIVA vs Inhalational Mode of Anaesthesia
NCT03807297 COMPLETED PHASE2