Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane
NCT ID: NCT02711917
Last Updated: 2016-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
175 participants
INTERVENTIONAL
2015-07-31
2016-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
NONE
Study Groups
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SP1- sevoflurane MAC 0.5
In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60.
MAC 0.5
0.5 MAC Sevoflurane
Propofol
Propofol consumption
Rocuronium
Consumption of Rocuronium
SP2- Sevoflurane MAC 0.75
In this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen.Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60.
MAC 0.75
0.75 MAC Sevoflurane
Propofol
Propofol consumption
Rocuronium
Consumption of Rocuronium
SP3 -Sevoflurane MAC 1.0
In this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 1.0. Propofol infusion is started to keep BIS between 40-60.
MAC 1.0
1.0 MAC Sevoflurane
Propofol
Propofol consumption
Rocuronium
Consumption of Rocuronium
SP4- Sevoflurane MAC 0.5
In this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60.
MAC 0.5
0.5 MAC Sevoflurane
Propofol
Propofol consumption
Rocuronium
Consumption of Rocuronium
SP5- Sevoflurane MAC 0.75
In this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60.
MAC 0.75
0.75 MAC Sevoflurane
Propofol
Propofol consumption
Rocuronium
Consumption of Rocuronium
SE1- Sevoflurane MAC 0.5
In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.
MAC 0.5
0.5 MAC Sevoflurane
Etomidate
Etomidate consumption
Rocuronium
Consumption of Rocuronium
SE2- Sevoflurane 0.75
In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.
MAC 0.75
0.75 MAC Sevoflurane
Etomidate
Etomidate consumption
Rocuronium
Consumption of Rocuronium
SE3- Sevoflurane MAC 1.0
In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.
MAC 1.0
1.0 MAC Sevoflurane
Etomidate
Etomidate consumption
Rocuronium
Consumption of Rocuronium
Interventions
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MAC 0.5
0.5 MAC Sevoflurane
MAC 0.75
0.75 MAC Sevoflurane
MAC 1.0
1.0 MAC Sevoflurane
Propofol
Propofol consumption
Etomidate
Etomidate consumption
Rocuronium
Consumption of Rocuronium
Eligibility Criteria
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Inclusion Criteria
* elective Gynaecological/abdominal/urological surgery
* Operation time \< 3hrs
* ASA I/II
* Intubated patients
Exclusion Criteria
* Severe uncontrolled HBP
* Obesity (BMI \>30)
* Neuromuscular and metabolic diseases
* Receiving medication known to influence neuromuscular transmission
* Pregnancy
* Psychiatric disorders
* Allergy history to any of the drugs that will be used
40 Years
ALL
Yes
Sponsors
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Tianjin Medical University General Hospital
OTHER
Responsible Party
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Guolin Wang
Professor
Principal Investigators
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Guolin Wang, Professor
Role: PRINCIPAL_INVESTIGATOR
Head of department anesthesiology
Other Identifiers
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Narina Goulvaden
Identifier Type: OTHER
Identifier Source: secondary_id
TianjinMUGH
Identifier Type: -
Identifier Source: org_study_id
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