Cultural Adaptation, Validation, and Evaluation of the Programme for Promotion of Healthy Affective-Sexual Behaviours in Adolescents (IYG)

NCT ID: NCT07208045

Last Updated: 2025-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-01

Study Completion Date

2027-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The investigators are writing to inform participants about a study being carried out by a research group from the University of Granada and the University of Seville, in which the participant's son/daughter is invited to participate. The study has been approved by the Provincial Research Ethics Committee of Granada under code 202499906944441.

The sole intention of the investigators is to ensure that participants receive correct and sufficient information to assess and decide whether or not to give consent for the child's participation in this study. The information sheet should be read carefully, and any questions may be addressed to the investigators.

The objective of the study is to culturally adapt the program It's Your Game: Keep it Real (IYG), which aims to prevent risky sexual and affective behaviors in adolescents. The IYG program consists of 12 lessons, each lasting 45 minutes. These lessons aim to help the child identify personal norms and boundaries regarding sexuality, recognize situations that might challenge these boundaries, and develop refusal skills to maintain them. The program also covers topics such as the characteristics of healthy and unhealthy relationships, friendships, anatomy and reproduction, the social, emotional, and physical consequences of sexual activity, the consequences of teenage pregnancy and STIs, condom and contraceptive use, and communication skills.

This adaptation will involve the child completing all 12 lessons (two lessons per week over a period of six weeks) that make up the IYG program, as well as filling out a series of questionnaires. These questionnaires will allow the investigators to assess the usability of the program in Spain (including ease of use, comprehension, acceptability, as well as aspects most liked and suggestions for improvement).

Participation is entirely VOLUNTARY AND ANONYMOUS, and consent may be withdrawn at any time, without providing any explanation and without this affecting the care the child will receive in any way.

In all cases, the CONFIDENTIALITY of the data collected will be maintained in accordance with the European Union General Data Protection Regulation (GDPR) 2016/679 and the Spanish Organic Law on the Protection of Personal Data and Guarantee of Digital Rights (LOPD-GDD) 3/2018, of December 5.

Regarding the study results, these may be shared with the scientific community through presentations, conferences, and/or publications.

The investigators express appreciation in advance for cooperation in this study.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sexual Behavior Sexually Transmitted Disease (STD) Condom Use Adolescent Health Cultural Adaptation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The pilot effectiveness study will be conducted through a randomised community trial with a Control Group (CG) and an Intervention Group (IG). For sample size calculation, assuming an alpha risk of 0.05 and a beta risk of 0.2 in a two-sided test, 300 participants are required in the first group and 300 in the second to detect a statistically significant difference between two proportions, expected to be 0.2 for group 1 and 0.1 for group 2. A 30% loss to follow-up rate has been estimated. So it is expected to recruit 600 students in each Region, Andalusia and Catalonia. The assignment of the Control Group (CG) and Intervention Group (IG) will be carried out through simple randomisation. For allocation, each educational centre will be assigned a number, and a random number generator will be used to determine its inclusion in either the CG or IG. Participants in the CG will remain on a waiting list to receive the intervention, which will be implemented once the project is completed.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Intervention group IYG

The intervention group will receive the culturally adapted version of It's Your Game (IYG) educational program, which is designed to promote healthy sexual behaviors and prevent risks among adolescents.

Group Type EXPERIMENTAL

Es tu juego: decide bien (IYG)

Intervention Type BEHAVIORAL

Affective-sexual education for adolescents through an gamified online and school-based program.

Waiting list control group

The control group will participate in the standard sexuality and emotional education training, corresponding to the regular curriculum implemented in the educational setting. The participants in the control group will remain on a waiting list to receive the intervention, which will be implemented once the project has been completed.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Es tu juego: decide bien (IYG)

Affective-sexual education for adolescents through an gamified online and school-based program.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adolescents aged between 11 and 14 years enrolled in compulsory secondary education (E.S.O).
* Access to a computer and internet at their educational centre.

Exclusion Criteria

* Presence of linguistic, cognitive, or sensory barriers that prevent completion of the questionnaire
* Participation in another programme aimed at preventing affective-sexual risk behaviours.
Minimum Eligible Age

11 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Seville

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Marta Lima-Serrano, PhD

Full professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Alba Sierra Yagüe, Phd Student

Role: PRINCIPAL_INVESTIGATOR

Catalan Institute of Health

Marta Lima Serrano, Full professor

Role: STUDY_DIRECTOR

University of Seville

José Antonio Zafra Agea, PhD

Role: PRINCIPAL_INVESTIGATOR

Catalan Institute of Health

Ana Aguilar Quesada, PhD Student

Role: PRINCIPAL_INVESTIGATOR

San Cecilio University Hospital, Granada

María González Cano Caballero, PhD

Role: PRINCIPAL_INVESTIGATOR

department of Nursing, Faculty of Health Sciences, University of Granada.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

IES Numancia

Barcelona, Santa Coloma de Gramenet, Spain

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Spain

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Alba Sierra Yagüe, PhD student. Nurse

Role: CONTACT

652260353

Marta Lima Serrano, Full professor

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Alba Sierra Yagüe

Role: primary

652260353

References

Explore related publications, articles, or registry entries linked to this study.

Wiltsey Stirman S, Baumann AA, Miller CJ. The FRAME: an expanded framework for reporting adaptations and modifications to evidence-based interventions. Implement Sci. 2019 Jun 6;14(1):58. doi: 10.1186/s13012-019-0898-y.

Reference Type BACKGROUND
PMID: 31171014 (View on PubMed)

Lucassen MF, Samra R, Brown KE, Rimes KA, Nunez-Garcia A, Wallace LM. A web-based intervention to support the mental well-being of sexual and gender minoritised adolescents: Formative evaluation of Oneself. Digit Health. 2025 Mar 13;11:20552076251321057. doi: 10.1177/20552076251321057. eCollection 2025 Jan-Dec.

Reference Type BACKGROUND
PMID: 40093712 (View on PubMed)

Escobar-Chaves SL, Shegog R, Moscoso-Alvarez MR, Markham C, Tortolero-Luna G, Peskin M, Tortolero S. Cultural tailoring and feasibility assessment of a sexual health middle school curriculum: a pilot test in Puerto Rico. J Sch Health. 2011 Aug;81(8):477-84. doi: 10.1111/j.1746-1561.2011.00617.x.

Reference Type BACKGROUND
PMID: 21740433 (View on PubMed)

Virzi RA. Refining the Test Phase of Usability Evaluation: How Many Subjects Is Enough? Human Factors: The Journal of the Human Factors and Ergonomics Society. 1992; 1; 34(4): 457-68. https://2024.sci-hub.box/3857/2afb54700f6961ae637e388c3f96891c/virzi1992.pdf

Reference Type BACKGROUND

Vargas-Martinez AM, Guillen-Martinez D, Domingo Perez T, Soilan Enriquez A, Zafra-Agea JA, Hoyos Cillero I, Lima-Serrano M, Tarrino-Concejero L. Analysis of the management function of the school nurse in Spain: use of records and interaction with primary care, the educational community and other institutions. Enferm Clin (Engl Ed). 2025 Sep-Oct;35(5):502200. doi: 10.1016/j.enfcle.2025.502200. Epub 2025 May 22.

Reference Type BACKGROUND
PMID: 40412717 (View on PubMed)

Agyei FB, Kaura DK, Bell JD. Parent-adolescent sexual and reproductive health information communication in Ghana. Reprod Health. 2025 Feb 19;22(1):25. doi: 10.1186/s12978-025-01961-y.

Reference Type BACKGROUND
PMID: 39972503 (View on PubMed)

Mukanga B, Dlamini SB, Taylor M. Cultural appropriateness of a comprehensive sexuality education programme. Implications for programme adaptation and implementation in Zambia. Sex Educ. 2025; 3;25(5): 631-46. https://doi.org/10.1080/14681811.2024.2367761

Reference Type BACKGROUND

Kitzinger J. Qualitative research. Introducing focus groups. BMJ. 1995 Jul 29;311(7000):299-302. doi: 10.1136/bmj.311.7000.299.

Reference Type BACKGROUND
PMID: 7633241 (View on PubMed)

Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007 Dec;19(6):349-57. doi: 10.1093/intqhc/mzm042. Epub 2007 Sep 14.

Reference Type BACKGROUND
PMID: 17872937 (View on PubMed)

Lee SD, Iott B, Banaszak-Holl J, Shih SF, Raj M, Johnson KE, Kiessling K, Moore-Petinak N. Application of Mixed Methods in Health Services Management Research: A Systematic Review. Med Care Res Rev. 2022 Jun;79(3):331-344. doi: 10.1177/10775587211030393. Epub 2021 Jul 12.

Reference Type BACKGROUND
PMID: 34253078 (View on PubMed)

Leech N, Onwuegbuzie A. Guidelines for conducting and reporting mixed research in the field of counseling and beyond. Journal of Counseling and Development. 2010; 88(1): 61-9. doi: 10.1002/j.1556-6678.2010.tb00151.x

Reference Type BACKGROUND

Muheriwa-Matemba S, Crooks N, Hall H et al. 156. Fostering Young Adolescent Engagement in Sexual Health Research: A Youth-Led Community-Based Participatory Research in Western NY. Journal of Adolescent Health. 2025; 76(3): S81. doi: 10.1016/j.jadohealth.2024.11.172

Reference Type BACKGROUND

Meherali S, Munro S, Puinean G, Salami B, Wong JP, Vandermorris A, Benoit JRA, Flicker S, Okeke-Ihejirika P, Stroulia E, Norman WV, Scott SD. Co-designing a Sexual Health App With Immigrant Adolescents: Protocol for a Qualitative Community-Based Participatory Action Research Study. JMIR Res Protoc. 2023 Mar 22;12:e45389. doi: 10.2196/45389.

Reference Type BACKGROUND
PMID: 36947124 (View on PubMed)

Kachingwe ON, Lewis Q, Offiong A, Smith BD, LoVette A, Powell TW. Using the intervention mapping for adaption framework to adapt an evidence-based sexual health intervention for youth affected by trauma. BMC Public Health. 2023 Jun 1;23(1):1052. doi: 10.1186/s12889-023-15984-2.

Reference Type BACKGROUND
PMID: 37264451 (View on PubMed)

Resnicow K, Baranowski T, Ahluwalia JS, Braithwaite RL. Cultural sensitivity in public health: defined and demystified. Ethn Dis. 1999 Winter;9(1):10-21.

Reference Type BACKGROUND
PMID: 10355471 (View on PubMed)

Bernal G, Bonilla J, Bellido C. Ecological validity and cultural sensitivity for outcome research: issues for the cultural adaptation and development of psychosocial treatments with Hispanics. J Abnorm Child Psychol. 1995 Feb;23(1):67-82. doi: 10.1007/BF01447045.

Reference Type BACKGROUND
PMID: 7759675 (View on PubMed)

Corpus-Espinosa C, Mac Fadden I, Del Carmen Torrejon-Guirado M, Lima-Serrano M. Exploring Cultural Adaptations: A Scoping Review on Adolescent Mental Health and Substance Use Prevention Programs. Prev Sci. 2025 Feb;26(2):204-221. doi: 10.1007/s11121-025-01779-x. Epub 2025 Jan 31.

Reference Type BACKGROUND
PMID: 39888521 (View on PubMed)

Flay BR, Petraitis J. The Theory of Triadic Influence: A New Theory of Health Behavior With Implications for Preventive Interventions. Advances in Medical Sociology 1994. https://www.researchgate.net/publication/224942196_The_Theory_of_Triadic_Influence_A_New_Theory_of_Health_Behavior_With_Implications_for_Preventive_Interventions

Reference Type BACKGROUND

Perry CL. Creating health behavior change: How to develop community-wide programs for youth. Sage Publications, editor. Thousand Oaks, California, USA; 1999.

Reference Type BACKGROUND

Komro KA, Perry CL, Williams CL, Stigler MH, Farbakhsh K, Veblen-Mortenson S. How did Project Northland reduce alcohol use among young adolescents? Analysis of mediating variables. Health Educ Res. 2001 Feb;16(1):59-70. doi: 10.1093/her/16.1.59.

Reference Type BACKGROUND
PMID: 11252284 (View on PubMed)

Bandura A. Social foundations of thought and action: a social cognitive theory. Englewood Cliffs: Prentice Hall; 1986.

Reference Type BACKGROUND

Lima-Serrano M, Barrera-Villalba C, Mac-Fadden I, Mesters I, de Vries H. Alerta Cannabis: A Tailored-Computer Web-Based Program for the Prevention of Cannabis Use in Adolescents: A Cluster-Randomized Controlled Trial Protocol. BMC Nurs. 2024 Apr 10;23(1):239. doi: 10.1186/s12912-024-01889-x.

Reference Type BACKGROUND
PMID: 38600496 (View on PubMed)

Shegog R, Craig Rushing S, Gorman G, Jessen C, Torres J, Lane TL, Gaston A, Revels TK, Williamson J, Peskin MF, D'Cruz J, Tortolero S, Markham CM. NATIVE-It's Your Game: Adapting a Technology-Based Sexual Health Curriculum for American Indian and Alaska Native youth. J Prim Prev. 2017 Apr;38(1-2):27-48. doi: 10.1007/s10935-016-0440-9.

Reference Type BACKGROUND
PMID: 27520459 (View on PubMed)

Shegog R, Peskin MF, Markham C, Thiel M, Karny E, Addy RC, Johnson KA, Tortolero S. It's Your Game-Tech: Toward Sexual Health in the Digital Age. Creat Educ. 2014 Aug;5(15):1428-1447. doi: 10.4236/ce.2014.515161.

Reference Type BACKGROUND
PMID: 25705561 (View on PubMed)

Peskin MF, Shegog R, Markham CM, Thiel M, Baumler ER, Addy RC, Gabay EK, Emery ST. Efficacy of It's Your Game-Tech: A Computer-Based Sexual Health Education Program for Middle School Youth. J Adolesc Health. 2015 May;56(5):515-21. doi: 10.1016/j.jadohealth.2015.01.001. Epub 2015 Mar 1.

Reference Type BACKGROUND
PMID: 25739520 (View on PubMed)

Markham CM, Tortolero SR, Peskin MF, Shegog R, Thiel M, Baumler ER, Addy RC, Escobar-Chaves SL, Reininger B, Robin L. Sexual risk avoidance and sexual risk reduction interventions for middle school youth: a randomized controlled trial. J Adolesc Health. 2012 Mar;50(3):279-88. doi: 10.1016/j.jadohealth.2011.07.010. Epub 2011 Oct 7.

Reference Type BACKGROUND
PMID: 22325134 (View on PubMed)

Tortolero SR, Markham CM, Peskin MF, Shegog R, Addy RC, Escobar-Chaves SL, Baumler ER. It's Your Game: Keep It Real: delaying sexual behavior with an effective middle school program. J Adolesc Health. 2010 Feb;46(2):169-79. doi: 10.1016/j.jadohealth.2009.06.008. Epub 2009 Aug 18.

Reference Type BACKGROUND
PMID: 20113923 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form: Infomed consent

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IYG2024

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Game Intervention for Resilience
NCT07235696 RECRUITING NA
Youth Compass Plus
NCT04340206 COMPLETED NA