CT KUB in Renal Cysts

NCT ID: NCT07187791

Last Updated: 2025-09-23

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-10-01
• Study Completion Date: 2027-10-31

Brief Summary

1. Primary (main):

1. Determine the diagnostic accuracy of CT KUB in differentiating between benign and suspicious renal cysts according to the Bosniak classification.

2. Secondary (subsidiary):

1. Assess interobserver agreement in CT KUB interpretation among radiologists with varying levels of expertise.

2. Identify limitations and pitfalls in the use of non-contrast CT KUB for characterizing renal cysts.

Detailed Description

Renal cysts are among the most frequently encountered incidental findings(1) on abdominal imaging, particularly with the increasing use of cross-sectional imaging. Most simple cysts are benign and require no further evaluation.

However, complex cystic lesions pose a diagnostic challenge, necessitating accurate characterization to distinguish benign from malignant lesions.(2).

While CT KUB is highly effective for detecting urinary tract stones, there are several limitations and pitfalls we should be aware of as Limited Soft Tissue Assessment as without contrast, masses, infections, or vascular lesions may not be clearly visible also some tumors called isodensity tumors, have similar intensity values to the surrounding normal tissues.(3).

Segmentation of kidney tumors on CT KUB images adds challenges compared to contrast-enhanced CT (CECT) images, due to low contrast and lack of multiphase images. On CECT images, the kidney tumors have different intensity values compared to the normal tissues.(4).

Validating CT KUB's accuracy in assessing renal cysts could have significant implications for clinical decision making, especially in resource-limited or urgent care settings

Conditions

CT KUB; Renal Cyst

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: PROSPECTIVE

Interventions

CT scan

All Patients will undergo CT KUB cyst evaluation Qualitatively regarding Gross Picture in Imaging and Quantitavely using Hausfield units then patients will undergo Abdomianl ultrasound

Intervention Type: DEVICE

Other Intervention Names

Ultrasound

Eligibility Criteria

Inclusion Criteria

• Patients referred for CT KUB with detectable Renal cysts

Exclusion Criteria

• 1-Patients with known renal tumors.
• 2-Inadequate imaging quality: CT KUB with severe motion/streak artifact or incomplete anatomical coverage preventing lesion assessment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Thomas Nabeel Mikha Saied

Resident Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Thomas Nabeel Saied, Resident Doctor

Role: CONTACT

tomaas.17289622@med.aun.edu.eg

+201012056837

Hisham Mostafa Imam, Professor

Role: CONTACT

hishimimam@aun.edu.eg

+201223971369

References

Forookhi, A., Bicchetti, M., Lucciola, S. et al. The thin line that made the difference: a case report on a Bosniak IIF renal cystic mass treated with cyst decortication. Egypt J Radiol Nucl Med 53, 115 (2022). https://doi.org/10.1186/s43055-022-00791-3

Reference Type: BACKGROUND

Smith AD, Remer EM, Cox KL, Lieber ML, Allen BC, Shah SN, Herts BR. Bosniak category IIF and III cystic renal lesions: outcomes and associations. Radiology. 2012 Jan;262(1):152-60. doi: 10.1148/radiol.11110888. Epub 2011 Nov 21.

Reference Type: BACKGROUND

PMID: 22106359 (View on PubMed)

Other Identifiers

CT in Renal cysts

Identifier Type: -

Identifier Source: org_study_id