Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)
NCT ID: NCT07121348
Last Updated: 2025-08-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
40 participants
INTERVENTIONAL
2025-07-28
2026-12-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Platelet Rich Fibrin (PRF only)
patients will recieve canal disinfection followed by induction of bleeding and placement of platelet rich fibrin as the only scaffold before coronal sealing.
platelet rich fibrin is obtained br removing the middle layer from a centrifuged blood sample and this is rich in platelets that play role in promoting tissue regeneration.
Platelet rich fibrin
platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Mesoporous Silica Nanoparticles scaffold (MSN)
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Mesoporous Silica Nanoparticles are biocompatible with high surface area that used as scaffold for enhancing the outcome.
Platelet rich fibrin
platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Hyaluronic Acid Nanoparticles scaffold (HA)
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Hyalornic Acid nanoparticles are biodegradable with high water retention capacity promoting pulp tissue regeneration.
Platelet rich fibrin
platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Pomegranate ( punica granatum) Extract Nanoparticles scaffold
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Pomegranate Extract Nanoparticles are synthesized from Punica granatum exract with potential antimicrobial and regenerative properties.
Platelet rich fibrin
platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Interventions
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Platelet rich fibrin
platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Teeth don't need for post and core as a final restoration.
* Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency.
* Teeth without anatomical variations
Exclusion Criteria
* Teeth with internal or external resorption
* Radiographic evidence of root fracture.
* Lack of patient and parent cooperation.
* Presence of periodontal pocket depth more than 4 mm.
9 Years
18 Years
ALL
No
Sponsors
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Tanta University
OTHER
Responsible Party
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Nada Ahmed Hashad
Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)
Locations
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Faculty of Dentistry,Tanta University
Tanta, Gharbia Governorate, Egypt
Countries
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Study Documents
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Document Type: Study Protocol
View DocumentRelated Links
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evaluate the antimicrobial effectiveness of two irrigation medication protocols
Other Identifiers
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REGEN2025-NH
Identifier Type: -
Identifier Source: org_study_id
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