Advanced PRF vs PRF for Gap Filling in Immediate Implants

NCT ID: NCT07319494

Last Updated: 2026-01-06

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-06-25
• Study Completion Date: 2026-02-15

Brief Summary

Study type: Clinical Trial

Goal:

The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement.

Main questions it aims to answer:

Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement?

Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF?

Comparison group:

Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes.

Participants will:

Undergo tooth extraction followed by immediate implant placement

Receive either A-PRF or PRF as the gap-filling material in the implant site

Have CBCT scans at baseline and 6 months to measure bone thickness

Have clinical assessments of soft tissue healing and implant stability

Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery

Conditions

Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

PRF Group

Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with traditional Platelet-Rich Fibrin (PRF) as the gap-filling material.

Group Type: EXPERIMENTAL

Immediate dental implant and PRF

Intervention Type: PROCEDURE

Arm 2: Platelet-Rich Fibrin (PRF) Participants will have a tooth extracted, the socket cleaned, and traditional PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.

A-PRF Group

Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with Advanced Platelet-Rich Fibrin (A-PRF) as the gap-filling material.

Group Type: EXPERIMENTAL

Immediate Dental Implant and A-PRF

Intervention Type: PROCEDURE

Arm 1: Advanced Platelet-Rich Fibrin (A-PRF) Participants will have a tooth extracted, the socket cleaned, and A-PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.

Interventions

Immediate Dental Implant and A-PRF

Arm 1: Advanced Platelet-Rich Fibrin (A-PRF) Participants will have a tooth extracted, the socket cleaned, and A-PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.

Intervention Type: PROCEDURE

Immediate dental implant and PRF

Arm 2: Platelet-Rich Fibrin (PRF) Participants will have a tooth extracted, the socket cleaned, and traditional PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• The selected patients has a badly decayed mandibular posterior teeth which are indicated for extraction due to dental causes (periapical abscess, trauma or caries) not periodontal as diagnosed by periapical x-ray.
• Healthy patients who are classified according to the American Society of Anesthesiologists (ASA)(2022) physical status classification as class I.
• Patient age ≥ 20 years old.
• Surgical site with sufficient for implant placement.
• Sufficient interocclusal space for prosthesis.
• Good oral hygiene.
• Patients have thick biotype.
• Patients have socket class I.

Exclusion Criteria

• Active periodontal diseases and periapical lesions not chronic infections.
• Patients have parafunctional
• History of alcohol or drug dependency, psychological factor that might affect the surgical or prosthodontic treatment.
• Smoking.
• Pregnant patients.
• Patients who are not willing to complete the study.

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beni-Suef University

OTHER

Sponsor Role: lead

Responsible Party

Eman Magdy Ahmed

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Delta University For Science And Technology

Al Mansurah, , Egypt

Countries

Egypt

Provided Documents

Document Type: Study Protocol

View Document

Other Identifiers

DU:024111959

Identifier Type: -

Identifier Source: org_study_id