Alveolar Ridge Preservation Following Tooth Extraction Using Advanced Platelet Rich Fibrin (A-PRF) Versus Platelet Rich Fibrin (PRF)
NCT ID: NCT04434703
Last Updated: 2021-01-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2020-11-01
2021-09-01
Brief Summary
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Detailed Description
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Anesthesia will be given then flapless atraumatic extraction using periotomes followed by forceps after luxation. For all groups, the socket will be debrided using curette then
* group A, the socket will be filled with A.PRF
* group B the socket will be filled with PRF.
* group C no bio-additive will be added.
* Criss cross horizontal mattress suture will be applied to close the extraction wound.
PRF and A-PRF preparation :
10 ml of blood will be drawn from each patient by vein puncture of the antecubital vein.
* Plateletr ich fibrin (PRF) is 3000 rpm and 10 minutes without addition of anticoagulant
* Advanced platelet rich fibrin (A-PRF) is 1300 rpm and 8 minutes.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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Platelet rich fibrin (PRF)
Platelet rich fibrin is the secoond generation of platelet concentrates which is an autogenous biomaterial that is prepared from the patient's own blood
Platelet rich fibrin (PRF)
following atraumatic extraction of the tooth using periotomes , 10 ml of patient's blood will be drawn by vein puncture of the antecubital vein and prepared in a centrifuge at 3000 rpm for 10 minutes then criss horizontal mattress suture will be applied to close the extraction wound
Advanced platelet rich fibrin (A-PRF)
Advanced platelet rich fibrin is the last modification of PRF which is expected to contain a relatively greater number of white blood cellsand growth factors
Advanced platelet rich fibrin (A-PRF)
following atraumatic extraction of the tooth using periotomes , 10 ml of patient's blood will be drawn by vein puncture of the antecubital vein and prepared in a centrifuge at 1300 rpm for 8 minutes then criss horizontal mattress suture will be applied to close the extraction wound
blood clot
normal healing of the wound without adding any biomaterial
blood clot
following atraumatic extraction of the tooth using periotomes, no bio-addative will be added and criss horizontal mattress suture will be applied to close the extraction wound
Interventions
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Platelet rich fibrin (PRF)
following atraumatic extraction of the tooth using periotomes , 10 ml of patient's blood will be drawn by vein puncture of the antecubital vein and prepared in a centrifuge at 3000 rpm for 10 minutes then criss horizontal mattress suture will be applied to close the extraction wound
Advanced platelet rich fibrin (A-PRF)
following atraumatic extraction of the tooth using periotomes , 10 ml of patient's blood will be drawn by vein puncture of the antecubital vein and prepared in a centrifuge at 1300 rpm for 8 minutes then criss horizontal mattress suture will be applied to close the extraction wound
blood clot
following atraumatic extraction of the tooth using periotomes, no bio-addative will be added and criss horizontal mattress suture will be applied to close the extraction wound
Eligibility Criteria
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Inclusion Criteria
* Stable periodontal condition with no acute periapical infection.
* Systematically healthy conditions.
* Cooperative patients.
* Intact buccal plate of bone.
Exclusion Criteria
* Patients seeking immediate or early implants.
* Pregnant females.
* Bone diseases.
* Drugs and diseases that may affect platelet count or function.
20 Years
60 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Reem Mahmoud AbdAlhameed AbuBasha
principal investigator
Locations
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School of dentistry , Cairo University
Cairo, , Egypt
Countries
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Other Identifiers
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6-3-1
Identifier Type: -
Identifier Source: org_study_id
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