Evaluation of Different Scaffolds in Regenerative Endodontic Treatment
NCT ID: NCT06945965
Last Updated: 2025-04-27
Study Results
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Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2021-09-01
2025-03-01
Brief Summary
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Radiographic outcomes (increase of root length, increase in thickness of dentinal wall, healing of periapical lesion, and apical closure).
Clinical outcomes in the treatment of young, immature permanent teeth with necrotic pulps.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Regeneration with Injectable platelet-rich fibrin (i-PRF) scaffold
10 ml of venous blood was drawn from the patient's arm. Then it was collected in a sterile tube without anticoagulant.
* The collected blood was centrifuged immediately.
* The separated plasma and platelets form a light-yellow-colored layer, which is situated at the top of the tube. This is then aspirated using a syringe with a needle and amounts to a partially active injectable form.
Injectable platelet-rich fibrin (i-PRF) scaffold
The separated plasma and platelets form a light-yellow-colored layer, which is situated at the top of the tube. This is then aspirated using a syringe with a needle (partially active injectable form).
Regeneration with platelet-rich fibrin (PRF)scaffold
10 ml venous blood was drawn from the patient's arm
* Then it was collected in a sterile tube without anticoagulant.
* The collected blood was centrifuged immediately.
* Following the centrifugation, the fibrin clot was formed in the middle of the tube between the red corpuscles at the bottom and acellular plasma at the top.
platelet-rich fibrin (PRF)scaffold
The fibrin clot was removed from the test tube with sterile tweezers, then cut into fragments, then placed incrementally in the canal space below the CEJ using hand pluggers (without prior induction of apical bleeding).
Regeneration with blood clot (BC) scaffold
The file will be passed 2 mm beyond the apical end to induce bleeding inside the canal till approximately 2-3 mm below the CEJ.
blood clot (BC) scaffold
A sterile saline-soaked cotton pellet was placed into the canal 2 mm below the orifice for 15 minutes to form a blood clot.
Interventions
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Injectable platelet-rich fibrin (i-PRF) scaffold
The separated plasma and platelets form a light-yellow-colored layer, which is situated at the top of the tube. This is then aspirated using a syringe with a needle (partially active injectable form).
platelet-rich fibrin (PRF)scaffold
The fibrin clot was removed from the test tube with sterile tweezers, then cut into fragments, then placed incrementally in the canal space below the CEJ using hand pluggers (without prior induction of apical bleeding).
blood clot (BC) scaffold
A sterile saline-soaked cotton pellet was placed into the canal 2 mm below the orifice for 15 minutes to form a blood clot.
Eligibility Criteria
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Inclusion Criteria
* Teeth not indicated for post/core final restoration.
* Radiographically: The root has incomplete development with an apical opening of more than 1 mm.
Exclusion Criteria
* Teeth with questionable restorability of the remaining crown/root structure.
* Pathological tooth mobility.
* Radiographically: Evidence of root fracture or root resorption (external or internal).
6 Years
25 Years
ALL
Yes
Sponsors
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British University In Egypt
OTHER
Responsible Party
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Riham Karam Ahmed
Ass.Lecturer
Principal Investigators
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shehab M Mohamed, Phd
Role: STUDY_DIRECTOR
British University In Egypt
Locations
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British University in Egypt
Cairo, , Egypt
Countries
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References
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Masuki H, Okudera T, Watanebe T, Suzuki M, Nishiyama K, Okudera H, Nakata K, Uematsu K, Su CY, Kawase T. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent. 2016 Dec;2(1):19. doi: 10.1186/s40729-016-0052-4. Epub 2016 Aug 22.
El Bagdadi K, Kubesch A, Yu X, Al-Maawi S, Orlowska A, Dias A, Booms P, Dohle E, Sader R, Kirkpatrick CJ, Choukroun J, Ghanaati S. Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). Eur J Trauma Emerg Surg. 2019 Jun;45(3):467-479. doi: 10.1007/s00068-017-0785-7. Epub 2017 Mar 21.
Metlerska J, Fagogeni I, Nowicka A. Efficacy of Autologous Platelet Concentrates in Regenerative Endodontic Treatment: A Systematic Review of Human Studies. J Endod. 2019 Jan;45(1):20-30.e1. doi: 10.1016/j.joen.2018.09.003. Epub 2018 Nov 13.
Murray PE. Platelet-Rich Plasma and Platelet-Rich Fibrin Can Induce Apical Closure More Frequently Than Blood-Clot Revascularization for the Regeneration of Immature Permanent Teeth: A Meta-Analysis of Clinical Efficacy. Front Bioeng Biotechnol. 2018 Oct 11;6:139. doi: 10.3389/fbioe.2018.00139. eCollection 2018.
Other Identifiers
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Regenerative Endodontic
Identifier Type: -
Identifier Source: org_study_id
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