Alveolar Ridge Preservation Using Autogenous Whole Tooth Graft With 1 %Metformin :A Randomized Controlled Clinical Trial

NCT ID: NCT07086859

Last Updated: 2025-07-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-30

Study Completion Date

2026-03-30

Brief Summary

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This study describes a technique used to preserve the bone dimensions after the tooth extraction inorder to facilitate later on the dental implant placement

Detailed Description

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Socket preservation by type of graft used from the tooth combined with Metformin to enhace the results of the bone formation

Conditions

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Dimensional Changes After Tooth Extraction Tooth Extraaction Socket Preservation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized Controlled Clinical Trial
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants
The patients participating in this clinical trial

Study Groups

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Test

Autogenous Whole tooth graft + Metformin in the socket of extracted non-molar tooth

Group Type EXPERIMENTAL

TEST 1

Intervention Type PROCEDURE

Autogenous whole tooth graft with metformin

Control

Autogenous whole tooth graft

Group Type ACTIVE_COMPARATOR

Control

Intervention Type PROCEDURE

Autogenous whole tooth graft

Interventions

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TEST 1

Autogenous whole tooth graft with metformin

Intervention Type PROCEDURE

Control

Autogenous whole tooth graft

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* patients requiring single extraction of non-molar tooth
* extraction sockets having more than 50% buccal alveolar bone loss

Exclusion Criteria

* Pregnancy
* smokers
* patients not maintaing good oral hygiene
* presernce of acute endodontic infection in the tooth to be ectracted
* medical conditions hindering implant placement
* uncontrolled diabetes
* Immune suppression
* bisphosphanates
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Nada Mohamed Hassan Gadallah

Masters Degree Candidate

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cairo Univeristy

Giza, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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Nada Gadallah, Masters Degree Candidate

Role: CONTACT

+201000130279

References

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Elfana A, El-Kholy S, Saleh HA, Fawzy El-Sayed K. Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clin Oral Implants Res. 2021 May;32(5):539-548. doi: 10.1111/clr.13722. Epub 2021 Mar 1.

Reference Type BACKGROUND
PMID: 33565656 (View on PubMed)

Related Links

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Other Identifiers

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279

Identifier Type: -

Identifier Source: org_study_id

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