Alveolar Ridge Preservation Using Different Bone Substitutes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-20

Study Completion Date

2019-01-20

Brief Summary

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The primary objective of this study was to compare the efficacy of using allograft, autogenous tooth graft, and beta-tricalcium phosphate for alveolar ridge preservation (ARP) by examining the alveolar ridge height and width at baseline and 3 months after the ARP both clinically and radiographically. The secondary objective was to evaluate the quality of the newly formed bone using histomorphometric analysis.

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Detailed Description

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This randomized controlled clinical trial included thirty patients. ARP was performed using either Allograft (Allograft group n=10), Tooth graft (Toothgraft group n=10), and beta tri-calcium- phosphate (beta tri-calcium group n=10). Changes in alveolar ridge dimensions were evaluated clinically and radiographically using cone beam computed tomography at baseline and 3 months. Core bone biopsy samples were obtained 3 months post-extraction during implant placement for histomorphometric analysis.

Conditions

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Alveolar Ridge Enlargement

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Alveolar ridge preservationwith tooth graft

tooth graft

Group Type ACTIVE_COMPARATOR

Toothgraft

Intervention Type DRUG

Particulate dentin

Alveolar ridge preservation with allograft

Allograft

Group Type ACTIVE_COMPARATOR

Allograft

Intervention Type DRUG

Mineralized corticocancellous allograft

Alveolar ridge preservation with alloplast

Beta Tri-Calcium phosphate

Group Type ACTIVE_COMPARATOR

Alloplast

Intervention Type DRUG

Beta tri-calcuim phosphate

Interventions

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Toothgraft

Particulate dentin

Intervention Type DRUG

Allograft

Mineralized corticocancellous allograft

Intervention Type DRUG

Alloplast

Beta tri-calcuim phosphate

Intervention Type DRUG

Other Intervention Names

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Mineralized corticocancellous allograft Beta tri-calcuim phosphate

Eligibility Criteria

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Inclusion Criteria

1. seeking implant-based restorations after tooth extraction.
2. exhibited no evidence of any significant medical history, measured using Burket's Oral medicine health history questionnaire.
3. exhibited Type I and II sockets

Exclusion Criteria

1. nonsmokers.
2. Pregnant and breast-feeding females
3. patients with known contraindications to dental implant surgery (e.g., increased bleeding tendency, history of treatments such as radiotherapy,

Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes