Antimicrobial Impact of Various RC Final Irrigation Activation Techniques

NCT ID: NCT07056127

Last Updated: 2025-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-01

Study Completion Date

2026-09-01

Brief Summary

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This randomized clinical study aims to evaluate microbial reduction in root canals after using different final irrigation activation techniques including passive ultrasonic irrigation, XP-endo Finisher file and Laser ablation with Indocyanine green dye in comparison to manual dynamic activation.

Detailed Description

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Conditions

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Root Canal Final Irrigation Activation Techniques

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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manual dynamic agitation

Group Type ACTIVE_COMPARATOR

manual dynamic agitaion

Intervention Type OTHER

5 mL of 2.5% NaOCl solution will be activated with a well-fitting gutta-percha cone that will be placed to full working length and then will be moved in push-pull strokes of 2 mm amplitude at a frequency of 100 strokes in about 1 min

ultrasonic activation

Group Type ACTIVE_COMPARATOR

ultrasonic activation

Intervention Type OTHER

5 mL of 5.25% NaOCl solution will be activated with PUI using a #20 endosonic file that will be driven by an ultrasonic device on medium power setting for 1 minute and inserted 1 mm short of the working length

xp-endo finisher

Group Type ACTIVE_COMPARATOR

xp-endo finisher

Intervention Type OTHER

5 mL of 5.25% NaOCl solution will be activated with XP-Endo Finisher which will be used in the canal for 1 minute at 800 rpm and 1 Ncm up to the working length and in slow up-and-down movements at 7-8mm length according to the manufacturer's recommendations

laser

Group Type ACTIVE_COMPARATOR

laser

Intervention Type OTHER

First, root canals will be filled with 0.5 mL of 0.05% ICG dye and left in place for 1 minute as preirradiation time. A #20 laser fiber will be inserted into the root canals to the working length. Then infrared diode laser with a wave length of 810 nm will be used to activate the dye for 30 seconds. For activation, circular movements will be performed along with the fiber removal movement . After the first activation, dye will be reintroduced, the laser fiber will be inserted again, and a new activation cycle of 30 seconds will be performed similarly to the previous one

Interventions

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manual dynamic agitaion

5 mL of 2.5% NaOCl solution will be activated with a well-fitting gutta-percha cone that will be placed to full working length and then will be moved in push-pull strokes of 2 mm amplitude at a frequency of 100 strokes in about 1 min

Intervention Type OTHER

ultrasonic activation

5 mL of 5.25% NaOCl solution will be activated with PUI using a #20 endosonic file that will be driven by an ultrasonic device on medium power setting for 1 minute and inserted 1 mm short of the working length

Intervention Type OTHER

xp-endo finisher

5 mL of 5.25% NaOCl solution will be activated with XP-Endo Finisher which will be used in the canal for 1 minute at 800 rpm and 1 Ncm up to the working length and in slow up-and-down movements at 7-8mm length according to the manufacturer's recommendations

Intervention Type OTHER

laser

First, root canals will be filled with 0.5 mL of 0.05% ICG dye and left in place for 1 minute as preirradiation time. A #20 laser fiber will be inserted into the root canals to the working length. Then infrared diode laser with a wave length of 810 nm will be used to activate the dye for 30 seconds. For activation, circular movements will be performed along with the fiber removal movement . After the first activation, dye will be reintroduced, the laser fiber will be inserted again, and a new activation cycle of 30 seconds will be performed similarly to the previous one

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

• Vital/non vital single rooted teeth with single root canal with nearly the same apical diameter requiring root canal treatment.

* Teeth with sound periodontal apparatus.

Exclusion Criteria

* • Teeth with anatomic anomilies.

* Retreatment cases
* Pregnant patients
Minimum Eligible Age

15 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Randa Ahmed Abdo Elsobky

Assistant teacher

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of dentistry

Tanta, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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Randa A Elsobky

Role: CONTACT

+201019980198

Facility Contacts

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faculty dentistry Faculty of dentistry

Role: primary

0403318537

Other Identifiers

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Irrigant activaion

Identifier Type: -

Identifier Source: org_study_id

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