Low-Flow Anesthesia and Open-Heart Surgery

NCT ID: NCT07040735

Last Updated: 2025-07-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-01

Study Completion Date

2026-02-01

Brief Summary

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Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L/min. In 1984, Baker and Simionescu classified LFA as 0.5-1 L/min and MFA as 0.25-0.5 L/min. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.

Detailed Description

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Conditions

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Low-flow Anesthesia Hemodynamics Open-heart Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

Followed using Bispectral Index (BIS) with 4% Sevoflurane and fresh gas flow set at 0.5 L/min

No interventions assigned to this group

Group 2

Followed using Minimum Alveolar Concentration (MAC) with 4% Sevoflurane and fresh gas flow set at 0.5 L/min

No interventions assigned to this group

Group 3

Followed using BIS with 4% Sevoflurane and fresh gas flow set at 1 L/min

No interventions assigned to this group

Group 4

Followed using MAC with 4% Sevoflurane and fresh gas flow set at 1 L/min

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

-≥18 years and scheduled for open-heart surgery patients

-ASA I-II-III-IV physical class

Exclusion Criteria

* Emergency cases
* Patients under 18 years of age
* Patients who have had open heart surgery before
* Patients for whom the use of inhaled anesthetic agents is contraindicated
* Patients who do not sign a voluntary consent form
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Çağrı Özdemir

OTHER

Sponsor Role lead

Responsible Party

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Çağrı Özdemir

asst. prof.

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Gazi University Faculty of Medicine

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Central Contacts

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Çağrı Özdemir

Role: CONTACT

+905544239196

Other Identifiers

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2025-146

Identifier Type: -

Identifier Source: org_study_id

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