We Analyse Metabolites in Dried Blood Spots From Newborns That Later in Life Developed an Eating Disorder.

NCT ID: NCT07016334

Last Updated: 2025-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-01

Study Completion Date

2027-12-31

Brief Summary

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Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation.

Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models

Detailed Description

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Conditions

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Eating Disorders

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Anorexia nervosa

Diagnosed (life-time) with anorexia nervosa

No interventions assigned to this group

Bulimia nervosa

Diagnosed (life-time) with bulimia nervosa

No interventions assigned to this group

Controls

Never diagnosed with anorexia or bulimia nervosa

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\- in PKU-register with or withou life-time diagnosis of anorexia or bulimi nervosa

Exclusion Criteria

* not in PKU register
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Ida AK Nilsson

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Karolinska Institutet

Stockholm, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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Analysis of blood spots in ED

Identifier Type: -

Identifier Source: org_study_id

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