Does Metabolic Syndrome Exist in Anorexia Nervosa?

NCT ID: NCT00271921

Last Updated: 2012-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-09-30

Study Completion Date

2007-06-30

Brief Summary

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The purpose of this study is to examine whether body fat distribution changes that occur with weight gain in women recovering from anorexia nervosa are transient or persistent, and if they are associated with other features of Metabolic Syndrome.

Detailed Description

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Conditions

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Anorexia Nervosa Metabolic Syndrome

Keywords

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eating disorders anorexia nervosa body fat distribution metabolic syndrome visceral adipose tissue

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Calorie controlled diet

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* DSM-IV diagnosis of Anorexia Nervosa (except amenorrhea) (restricting or binge eating/purging subtype)
* Female
* Age 18-40
* Medically stable
* Participation in inpatient or daypatient treatment sufficient to restore patient to a BMI of at least 19.5kg/m²

Exclusion Criteria

* Additional Major Axis I disorder (including substance abuse or dependence
* On daily prescription medication (including oral contraceptives)
* History of suicide attempt or other self-injurious behavior within the previous 6 months
* Significant current or past medical illness,including diabetes mellitus, heart disease
* Indwelling metallic object (e.g., pacemaker,pump), non-removable metal jewelry or recent metallic ink tattoo
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role lead

Principal Investigators

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Laurel Mayer, MD

Role: PRINCIPAL_INVESTIGATOR

New York State Psychiatric Institute/Columbia University

Henry Ginsberg, MD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

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St. Luke's Roosevelt Hosptial Center

New York, New York, United States

Site Status

New York State Psychiatric Institute/Columbia University

New York, New York, United States

Site Status

Countries

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United States

References

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Schebendach J, Mayer LE, Devlin MJ, Attia E, Walsh BT. Dietary energy density and diet variety as risk factors for relapse in anorexia nervosa: a replication. Int J Eat Disord. 2012 Jan;45(1):79-84. doi: 10.1002/eat.20922. Epub 2011 Mar 29.

Reference Type DERIVED
PMID: 21448937 (View on PubMed)

Bodell LP, Mayer LE. Percent body fat is a risk factor for relapse in anorexia nervosa: a replication study. Int J Eat Disord. 2011 Mar;44(2):118-23. doi: 10.1002/eat.20801.

Reference Type DERIVED
PMID: 20127939 (View on PubMed)

Mayer LE, Klein DA, Black E, Attia E, Shen W, Mao X, Shungu DC, Punyanita M, Gallagher D, Wang J, Heymsfield SB, Hirsch J, Ginsberg HN, Walsh BT. Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. Am J Clin Nutr. 2009 Nov;90(5):1132-7. doi: 10.3945/ajcn.2009.27820. Epub 2009 Sep 30.

Reference Type DERIVED
PMID: 19793856 (View on PubMed)

Other Identifiers

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R03DK066033

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R03 DK66033 (completed)

Identifier Type: -

Identifier Source: org_study_id