Effects of Intermittent Running on Metabolic Health

NCT ID: NCT06962605

Last Updated: 2026-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-21

Study Completion Date

2026-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine whether similar or greater effects can be achieved for glycemic control in recreationally active adults.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The same procedure will be repeated for all trials: Participants will be asked to perform 3 trials in a randomized-crossover design \[moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN; 50% and 70% V̇O2max), 2-minute interval running (2MIN; 50% and 70% V̇O2max)\]. All trials will be separated by at least 4 days wash-out and less than 14 days between trials to ensure complete rest.

Sensors for measuring muscle oxygen (10 cm proximal to the mid-patella, and 2 cm lateral) will be placed on the rectus femoris muscle and 15 min resting metabolic rate was measured. After baseline measurements, participants warm-up for 3 minutes with fixed walking intensity (i.e., 5 km/h) followed by 40 minutes running. Immediately after the running, participants return to a seated position for 30 minutes post-exercise measurements (EPOC).

During the EPOC and resting metabolic rate (RMR) measurement participants will sit in a comfortable position and need to limit fidgeting, thus allowed only to watch TV or videos on their phone. Participants will be wheeled to the bathroom if needed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Metabolic Regulation Energy Expenditure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Participants will be asked to perform 4 trials in a randomized-crossover design (1) moderate-intensity continuous running (MICE: 60% V̇O2max), (2) 5-minute interval running (5MIN; 50% and 70% V̇O2max), (3) 2-minute interval running (2MIN; 50% and 70% V̇O2max).
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Moderate-intensity continuous running (MICE: 60% V̇O2max)

Exercise

Group Type EXPERIMENTAL

Moderate-intensity continuous running (MICE: 60% V̇O2max)

Intervention Type BEHAVIORAL

Participants run continuously for 40 minutes at moderate intensity (60-65% V̇O2max)

5-minute interval running (5MIN)

Exercise

Group Type EXPERIMENTAL

5-minute interval running (5MIN)

Intervention Type BEHAVIORAL

Participants run for 40 minutes at average moderate intensity with 5-minutes slow and fast cycles where speed is increased and decreased by 20%.

2-minute interval running (2MIN)

Exercise

Group Type EXPERIMENTAL

2-minute interval running (2MIN)

Intervention Type BEHAVIORAL

Participants run for 40 minutes at average moderate intensity with 2-minutes slow and fast cycles where speed is increased and decreased by 20%.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Moderate-intensity continuous running (MICE: 60% V̇O2max)

Participants run continuously for 40 minutes at moderate intensity (60-65% V̇O2max)

Intervention Type BEHAVIORAL

5-minute interval running (5MIN)

Participants run for 40 minutes at average moderate intensity with 5-minutes slow and fast cycles where speed is increased and decreased by 20%.

Intervention Type BEHAVIORAL

2-minute interval running (2MIN)

Participants run for 40 minutes at average moderate intensity with 2-minutes slow and fast cycles where speed is increased and decreased by 20%.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy recreationally active men
* BMI between 18.5-27 kg/m2
* Aged between 20 to 45 years
* Regular exercise (3 times per week and longer than 3 months) with cardio exercise longer than 30 minutes at least once a week
* Weight stable for more than 3 months (no change in weight +/- 3%)
* Non-shift workers and sleep at least 6.5-9 hours for the past 3 months
* Non-smoker

Exclusion Criteria

* having any cardiovascular, metabolic or pulmonary disease (angina pectoris or uncontrolled arrhythmias)
* suffering from infectious contagious diseases,
* using medications that could affect metabolic responses (including anti-inflammatory medications)
* smoking
* heavy alcohol intake (more than 4 drinks on any day or more than 14 drinks a week).
* undergoing special diets (e.g., intermittent fasting and/or ketogenic diets)
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Taiwan Normal University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Yung-Chih Chen

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

National Taiwan Normal University

Taipei, , Taiwan

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Taiwan

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Yung-Chih Chen, PhD

Role: CONTACT

+886277496979

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

202502HM010

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.