Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-27

Study Completion Date

2025-09-30

Brief Summary

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The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa. In addition, the investigators will learn about the safety of ozonated water and hypochlorous acid solution. The main questions that participants need to answer are:

What medical conditions do participants have while taking ozonated water and hypochlorous acid solution?

Investigators will compare ozonated water and hypochlorous acid solution with 0.12% chlorhexidine gluconate solution to see if it helps to restore the integrity of the oral mucosa.

Participants:

Participants will be asked to agree to receive oral care 4 times a day, every day for 1 week.

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Detailed Description

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Conditions

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Oral Mucosal Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Experimental 1

Ozonated water

Group Type EXPERIMENTAL

Control 1

Intervention Type DRUG

Researchers will perform oral care with ozonated water and hypochlorous acid solution to restore oral mucous membrane integrity.

Experimental 2

hypochlorous acid

Group Type EXPERIMENTAL

Control 1

Intervention Type DRUG

Researchers will perform oral care with ozonated water and hypochlorous acid solution to restore oral mucous membrane integrity.

Control 1

%0.12 chlorhexidine gluconate

Group Type ACTIVE_COMPARATOR

Control 1

Intervention Type DRUG

Researchers will perform oral care with ozonated water and hypochlorous acid solution to restore oral mucous membrane integrity.

Interventions

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Control 1

Researchers will perform oral care with ozonated water and hypochlorous acid solution to restore oral mucous membrane integrity.

Intervention Type DRUG

Other Intervention Names

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%0.12 chlorhexidine gluconate

Eligibility Criteria

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Inclusion Criteria

* Be between the ages of 18-65,
* Have been on mechanical ventilation for at least 24 hours,
* Have no intolerance or allergy to the solutions,
* Agree to participate in the study