Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Levels

NCT ID: NCT04946617

Last Updated: 2021-07-01

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 120 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-07-20
• Study Completion Date: 2021-12-20

Brief Summary

Recent studies have shown that while mouthwashes exhibit antimicrobial properties against bacteria and their products, at the same time showing the cytotoxic effect on living cells in the mouth.29 To the best of our knowledge, there is no information about the toxicity effect of these two mouthwashes, which are highly preferred, on antimicrobial peptides secreted from the oral epithelium. Therefore, our aim in this study is to evaluate the effect of chlorhexidine and essential oil mouthwash on hBD2 and LL-37 in saliva.

Detailed Description

Periodontal health continues with a balanced interaction of the oral microflora with the host defense line.

Conditions

Mouth and Tooth Diseases; Periodontal Diseases; Gingivitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

H group

healthy periodontium, BOP at \\20 % of the sites and no sites with probing depth (PD) \[3 mm and clinical attachment level (CAL) \[2 mm or alveolar bone loss (N = 20, 12 males, 8 females, mean age: 33.38

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Intervention Type: DRUG

Rinsing with mouthwashes

G group

gingivitis, BOP at ≥20 % of the sites and no sites with PD and CAL \[3 mm or bone loss (N = 20, 6 males, 14 females, mean age: 32.35);

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Intervention Type: DRUG

Rinsing with mouthwashes

CP group

chronic periodontitis, ≥4 teeth in each jaw with PD of ≥5 mm, CAL of C4 mm, BOP at \[≥80 % of the proximal sites and radiographic evidence of interproximal bone loss

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Intervention Type: DRUG

Rinsing with mouthwashes

Interventions

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Rinsing with mouthwashes

Intervention Type: DRUG

Other Intervention Names

Mouthwash Product

Eligibility Criteria

Inclusion Criteria

1. systemically healthy,

2. presence of ≥20 natural teeth,

3. agreement to participate in the study .

Exclusion Criteria

1. known systemic illness,

2. smoking habit,

3. pregnancy/ lactation,

4. long-term use of anti-inflammatory drugs.

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Istanbul Medeniyet University

OTHER

Sponsor Role: lead

Responsible Party

Mustafa Cihan Yavuz

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mustafa C Yavuz, PhD

Role: PRINCIPAL_INVESTIGATOR

Istanbul Medeniyet University

Central Contacts

Mustafa C Yavuz, PhD

Role: CONTACT

muscyz111@gmail.com

+905056429856

References

Van Dyke TE. Pro-resolving mediators in the regulation of periodontal disease. Mol Aspects Med. 2017 Dec;58:21-36. doi: 10.1016/j.mam.2017.04.006. Epub 2017 May 18.

Reference Type: BACKGROUND

PMID: 28483532 (View on PubMed)

Other Identifiers

9.2.2017-30

Identifier Type: -

Identifier Source: org_study_id