Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ
NCT ID: NCT02946814
Last Updated: 2016-10-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
20 participants
INTERVENTIONAL
2016-10-31
Brief Summary
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An appliance was designed to hold six glass disks on the buccal sides of the lower teeth, allowing PL-biofilm growth. Twenty healthy volunteers will the appliance for 48 h and then performed a mouthwash with essential oils. Disks will be removed after 30 s and at 1, 3, 5, and 7 h later. After a washout period, the same procedure will be repeated with a sterile water mouthwash and a mouthwash with essential oils without alcohol. After PL-biofilm vital staining, samples will be analyzed using a confocal laser scanning microscope analysing their bacterial viability and thickness.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
DOUBLE
Study Groups
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essential oils
a single mouthwash with 20 ml of essential oils for 30 seconds.
essential oils
essential oils without mouthwash
a single mouthwash with 20 ml of essential oils without alcohol for 30 seconds.
essential oils without mouthwash
sterile water
a single mouthwash with 20 ml of sterile water for 30 seconds.
sterile water
Interventions
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essential oils
essential oils without mouthwash
sterile water
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Minimum of 24 permanent teeth.
* No gingivitis (Community Periodontal Index score = 0).
* No periodontitis (Community Periodontal Index score = 0).
* Absence of untreated caries.
Exclusion Criteria
* Presence of dental prostheses.
* Presence of orthodontic devices.
* Antibiotic treatment or routine use of oral antiseptics in the previous 3 months.
* Presence of any systemic disease that could alter the production or composition of saliva.
18 Years
ALL
Yes
Sponsors
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University of Santiago de Compostela
OTHER
Responsible Party
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Inmaculada Tomas
Senior Lecturer
References
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Quintas V, Prada-Lopez I, Prados-Frutos JC, Tomas I. In situ antimicrobial activity on oral biofilm: essential oils vs. 0.2 % chlorhexidine. Clin Oral Investig. 2015 Jan;19(1):97-107. doi: 10.1007/s00784-014-1224-3. Epub 2014 Apr 1.
Other Identifiers
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substantivity 2016
Identifier Type: -
Identifier Source: org_study_id